Quantitative comparison of myocardial fiber structure between mice, rabbit, and sheep using diffusion tensor cardiovascular magnetic resonance

Accurate interpretations of cardiac functions require precise structural models of the myocardium, but the latter is not available always and for all species. Although scaling or substitution of myocardial fiber information from alternate species has been used in cardiac functional modeling, the val...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiovascular magnetic resonance 2011-11, Vol.13 (1), p.74-74, Article 74
Main Authors: Healy, Lindsey J, Jiang, Yi, Hsu, Edward W
Format: Article
Language:English
Subjects:
Animals
Care and treatment
Diagnosis
Diffusion
Diffusion Tensor Imaging
Fiber orientation
Fibers
Heart
Heart diseases
Heart Ventricles - cytology
Magnetic resonance imaging
Male
Mathematical analysis
Mice
Mice, 129 Strain
Myocytes, Cardiac
Rabbits
Sheep
Species Specificity
Tensors
Tissue Fixation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Accurate interpretations of cardiac functions require precise structural models of the myocardium, but the latter is not available always and for all species. Although scaling or substitution of myocardial fiber information from alternate species has been used in cardiac functional modeling, the validity of such practice has not been tested. Fixed mouse (n = 10), rabbit (n = 6), and sheep (n = 5) hearts underwent diffusion tensor imaging (DTI). The myocardial structures in terms of the left ventricular fiber orientation helix angle index were quantitatively compared between the mouse rabbit and sheep hearts. The results show that significant fiber structural differences exist between any two of the three species. Specifically, the subepicardial fiber orientation, and the transmural range and linearity of fiber helix angles are significantly different between the mouse and either rabbit or sheep. Additionally, a significant difference was found between the transmural helix angle range between the rabbit and sheep. Across different circumferential regions of the heart, the fiber orientation was not found to be significantly different. The current study indicates that myocardial structural differences exist between different size hearts. An immediate implication of the present findings for myocardial structural or functional modeling studies is that caution must be exercised when extrapolating myocardial structures from one species to another.
ISSN:1097-6647
1532-429X
1532-429X
DOI:10.1186/1532-429X-13-74