Research on the anti-oxidant and anti-aging effects of Polygonatum kingianum saponins in Caenorhabditis elegans

Oxidative stress and its impact on aging are critical areas of research. Natural anti-oxidants, such as saponins found in Polygonatum sibiricum, hold promise as potential clinical interventions against aging. In this study, we utilized the nematode model organism, Caenorhabditis elegans, to investig...

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Bibliographic Details
Published in:Heliyon 2024-08, Vol.10 (15), p.e35556, Article e35556
Main Authors: Huang, Yaqi, Wang, Yetong, Deng, Jia, Gao, Sijie, Qiu, Jiakang, He, Jiawei, Yang, Tong, Tan, Nianhua, Cheng, Shaowu, Song, Zhenyan
Format: Article
Language:English
Subjects:
Anti-aging
Anti-oxidant
Caenorhabditis elegans
Polygonatum kingianum saponins
SKN-1
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Summary:Oxidative stress and its impact on aging are critical areas of research. Natural anti-oxidants, such as saponins found in Polygonatum sibiricum, hold promise as potential clinical interventions against aging. In this study, we utilized the nematode model organism, Caenorhabditis elegans, to investigate the pharmacological effects of Polygonatum sibiricum saponins (PKS) on antioxidation and anti-aging. The results demonstrated a significant anti-aging biological activity associated with PKS. Through experiments involving lifespan and stress, lipofuscin, q-PCR, and ROS measurement, we found that PKS effectively mitigated aging-related processes. Furthermore, the mechanism underlying these anti-aging effects was linked to the SKN-1 signaling pathway. PKS increased the nuclear localization of the SKN-1 transcription factor, leading to the up-regulation of downstream anti-oxidant genes, such as gst-4 and sod-3, and a substantial reduction in intracellular ROS levels within the nematode. In conclusion, our study sheds light on the anti-oxidant and anti-aging properties of PKS in C. elegans. This research not only contributes to understanding the biological mechanisms involved but also highlights the potential therapeutic applications of these natural compounds in combating aging-related processes.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e35556