Effective Mosquito Repellents: Myrcene- and Cymene-Loaded Nanohydrogels against Aedes aegypti

Aedes mosquito-borne diseases remain a significant global health threat, necessitating effective control strategies. This study introduces monoterpenes-based nanohydrogels for potential use as repellents against , the primary dengue vector worldwide. We formulated hydrogels using cymene- and myrcene...

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Published in:Pharmaceutics 2024-08, Vol.16 (8), p.1096
Main Authors: Duarte, Jonatas Lobato, Di Filippo, Leonardo Delello, Ribeiro, Tais de Cássia, Silva, Ana Carolina de Jesus, Hage-Melim, Lorane Izabel da Silva, Duchon, Stéphane, Carrasco, David, Pinto, Mara Cristina, Corbel, Vincent, Chorilli, Marlus
Format: Article
Language:English
Subjects:
arboviruses
carboxymethylcellulose
cymene
Hydrogels
Insecticides
Mosquitoes
myrcene
nanoemulsion
Nanoemulsions
Oils & fats
Polymers
Rheology
Skin
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Summary:Aedes mosquito-borne diseases remain a significant global health threat, necessitating effective control strategies. This study introduces monoterpenes-based nanohydrogels for potential use as repellents against , the primary dengue vector worldwide. We formulated hydrogels using cymene- and myrcene-based nanoemulsions with different polymers: chitosan, carboxymethylcellulose (CMC), and carbopol . Our evaluations of rheological, texture, and bioadhesive properties identified CMC hydrogel as the most promising gelling agent for topical application, exhibiting sustained monoterpene release over 12 h with low skin permeation and high retention in the stratum corneum. Myrcene-loaded CMC hydrogel achieved a 57% feeding deterrence compared to 47% with cymene hydrogel in the mosquito membrane-feeding model. Molecular docking studies revealed interactions between myrcene and an essential amino acid (Ile116) in the odorant-binding protein 22 (AeOBP22), corroborating its higher repellent efficacy. These findings suggest that myrcene-loaded CMC hydrogels offer a promising, minimally invasive strategy for personal protection against and warrant further investigation to optimize monoterpene concentrations for vector control.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16081096