Correspondence: Cancer incidence and mortality after a first-ever venous thrombosis in northern Sweden

We congratulate Hägg et al. on their study investigating cancer incidence and mortality following first-ever venous thromboembolism (VTE), which provides valuable insights into VTE as a potential marker for underlying malignancies. However, we highlight concerns regarding healthy user bias, the uncl...

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Bibliographic Details
Published in:Thrombosis journal 2024-11, Vol.22 (1), p.96-2, Article 96
Main Authors: Tran, Minh-Hoang, Truong-Nguyen, Kim-Huong
Format: Article
Language:English
Subjects:
Analysis
Cancer
Health aspects
Matters Arising
Mortality
neoplasm
Oncology, Experimental
Thromboembolism
venous thromboembolism
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Summary:We congratulate Hägg et al. on their study investigating cancer incidence and mortality following first-ever venous thromboembolism (VTE), which provides valuable insights into VTE as a potential marker for underlying malignancies. However, we highlight concerns regarding healthy user bias, the unclear follow-up duration, and inconsistent adjustment in the statistical analysis. We also suggest the use of the Fine-Gray subdistribution hazard model to address competing risks, and the accurate reporting of sex-gender terminology. Lastly, we advise caution in concluding a high incidence of cancer following first-ever VTE without pre-VTE data for comparison and recommend acknowledging potential surveillance bias when interpreting the higher cancer detection rate within 6 months of VTE diagnosis.
ISSN:1477-9560
1477-9560
DOI:10.1186/s12959-024-00667-8