TOR1B: a predictor of bone metastasis in breast cancer patients

Recent therapeutic advances in breast cancer (BC) have improved survival outcomes; however, the prognosis for patients with bone metastasis (BM) remains poor. Hence, novel clinical biomarkers are needed to accurately predict BC BM as well as to promote personalized medicine. Here, we discovered a no...

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Bibliographic Details
Published in:Scientific reports 2023-01, Vol.13 (1), p.1495-1495, Article 1495
Main Authors: Nguyen, Minh Nam, Akter, Salima, Akhter, Hajara, Ansary, Shahina, Han, Sunhee, Shin, Yoonhwa, Ha, Joohun, Kang, Insug, Kim, Sung Soo, Choi, Tae Gyu
Format: Article
Language:English
Subjects:
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Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Bone cancer
Bone Neoplasms - genetics
Breast cancer
Breast Neoplasms - pathology
Cell Nucleus - metabolism
Endoplasmic reticulum
Female
Gene expression
Humanities and Social Sciences
Humans
Medical prognosis
Metastases
Metastasis
multidisciplinary
Precision medicine
Prognosis
Science
Science (multidisciplinary)
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Summary:Recent therapeutic advances in breast cancer (BC) have improved survival outcomes; however, the prognosis for patients with bone metastasis (BM) remains poor. Hence, novel clinical biomarkers are needed to accurately predict BC BM as well as to promote personalized medicine. Here, we discovered a novel biomarker, TOR1B, for BM in BC patients via analysis of BC gene expression data and clinical information downloaded from open public databases. In cancer cells, we found high expression levels of TOR1B in the nucleus and endoplasmic reticulum. Regarding gene expression, the level of TOR1B was significantly upregulated in BC patients with BM ( p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-28140-y