Woven Vascular Stent-Grafts with Surface Modification of Silk Fibroin-Based Paclitaxel/Metformin Microspheres

In-stent restenosis caused by tumor ingrowth increases the risk of secondary surgery for patients with abdominal aortic aneurysms (AAA) because conventional vascular stent grafts suffer from mechanical fatigue, thrombosis, and endothelial hyperplasia. For that, we report a woven vascular stent-graft...

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Bibliographic Details
Published in:Bioengineering (Basel) 2023-03, Vol.10 (4), p.399
Main Authors: Liang, Mengdi, Li, Fang, Wang, Yongfeng, Chen, Hao, Tian, Jingjing, Zhao, Zeyu, Schneider, Karl H, Li, Gang
Format: Article
Language:English
Subjects:
Aneurysms
Aorta
Aortic aneurysms
Biocompatibility
Bioengineering
Contact angle
Drug delivery
drug release
Electrostatic bonding
Emulsification
Endothelial cells
Grafting
Hyperplasia
Immunosuppressive agents
Implants
Mechanical properties
Membranes
Metformin
Microspheres
Morphology
Paclitaxel
Permeability
Polyethylene glycol
Restenosis
Scanning electron microscopy
Self-assembly
Silk
Silk fibroin
Stent (Surgery)
stent-graft
Stents
Tensile strength
Thrombosis
Titanium alloys
Umbilical vein
Veins & arteries
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Summary:In-stent restenosis caused by tumor ingrowth increases the risk of secondary surgery for patients with abdominal aortic aneurysms (AAA) because conventional vascular stent grafts suffer from mechanical fatigue, thrombosis, and endothelial hyperplasia. For that, we report a woven vascular stent-graft with robust mechanical properties, biocompatibility, and drug delivery functions to inhibit thrombosis and the growth of AAA. Paclitaxel (PTX)/metformin (MET)-loaded silk fibroin (SF) microspheres were self-assembly synthesized by emulsification-precipitation technology and layer-by-layer coated on the surface of a woven stent via electrostatic bonding. The woven vascular stent-graft before and after coating drug-loaded membranes were characterized and analyzed systematically. The results show that small-sized drug-loaded microspheres increased the specific surface area and promoted the dissolution/release of drugs. The stent-grafts with drug-loaded membranes exhibited a slow drug-release profile more for than 70 h and low water permeability at 158.33 ± 17.56 mL/cm ·min. The combination of PTX and MET inhibited the growth of human umbilical vein endothelial cells. Therefore, it was possible to generate dual-drug-loaded woven vascular stent-grafts to achieve the more effective treatment of AAA.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering10040399