Thrombotic Disease in Hemophilic Patients: Is This a Paradox in a State of Hypocoagulability?

Hemophilia patients have a deficiency in or dysfunction of clotting factors, which can lead to a bleeding tendency. However, paradoxically, some hemophilia patients may also be at an increased risk of developing thrombotic events such as deep vein thrombosis or pulmonary embolism. The pathophysiolog...

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Bibliographic Details
Published in:Diagnostics (Basel) 2024-01, Vol.14 (3), p.286
Main Authors: Badulescu, Oana Viola, Badescu, Minerva Codruta, Bojan, Iris Bararu, Vladeanu, Maria, Filip, Nina, Dobreanu, Stefan, Tudor, Razvan, Ciuntu, Bogdan-Mihnea, Tanevski, Adelina, Ciocoiu, Manuela
Format: Article
Language:English
Subjects:
Blood clot
Blood platelets
clotting factors
Disease
Families & family life
Family medical history
Females
Gene mutations
Genes
Genetic aspects
Hemophilia
HIV
Human immunodeficiency virus
Iloprost
Males
Mortality
Mutation
Obesity
Pathophysiology
Pulmonary embolism
Risk factors
Surgery
Thromboembolism
Thrombosis
Trauma
X chromosomes
Y chromosomes
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Summary:Hemophilia patients have a deficiency in or dysfunction of clotting factors, which can lead to a bleeding tendency. However, paradoxically, some hemophilia patients may also be at an increased risk of developing thrombotic events such as deep vein thrombosis or pulmonary embolism. The pathophysiology of thrombosis in hemophilia patients is not fully understood, but it is thought to involve a complex interplay of various factors, including the severity of the hemophilia, the presence of other risk factors such as obesity, smoking, or the use of hormonal therapies, and the presence of certain genetic mutations that increase the risk of thrombosis. In addition, it has been suggested that the use of clotting factor replacement therapy, which is a standard treatment for hemophilia, may also contribute to the development of thrombosis in some cases.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14030286