Antibody responses to BNT162b2 SARS‐CoV‐2 mRNA vaccine among healthcare workers and residents of long‐term care facilities: A cohort study in Northern Italy

Background and Aims Long‐term care facilities (LTCFs) have been severely impacted by COVID‐19, with a disproportionate amount of SARS‐CoV‐2 infections and related deaths occurring among residents. Methods This study is part of an ongoing multicenter, prospective cohort study conducted among healthca...

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Bibliographic Details
Published in:Health science reports 2023-02, Vol.6 (2), p.e1087-n/a
Main Authors: Vicentini, Costanza, Zotti, Carla Maria, Cornio, Alessandro Roberto, Garlasco, Jacopo, Marengo, Noemi, Meddis, Davide, Ditommaso, Savina, Giacomuzzi, Monica, Memoli, Gabriele, Bordino, Valerio, Gianino, Maria Michela
Format: Article
Language:English
Subjects:
Antibodies
Clinical trials
Cohort analysis
Coronaviruses
COVID-19 vaccines
Disease transmission
immune senescence
Immunization
Immunoglobulins
Infections
Italy
Laboratories
Long term health care
Medical personnel
mRNA vaccines
nursing homes
Original Research
Pfizer/BNT162b2
Polymerase chain reaction
SARS‐CoV‐2
Severe acute respiratory syndrome coronavirus 2
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Summary:Background and Aims Long‐term care facilities (LTCFs) have been severely impacted by COVID‐19, with a disproportionate amount of SARS‐CoV‐2 infections and related deaths occurring among residents. Methods This study is part of an ongoing multicenter, prospective cohort study conducted among healthcare workers (HCWs) and residents of 13 LTCFs in Northern Italy designed to evaluate SARS‐CoV‐2 specific immunoglobulin class G (IgG) titers before and following vaccination with Pfizer/BNT162b2 SARS‐CoV‐2 mRNA vaccine (two doses of vaccine, 21 days apart). Serum samples were obtained from participants (t0) before vaccination, and (t1) 2 weeks after and analyzed to determine anti‐S1 IgG antibodies. Results Five hundred and thirty‐four participants were enrolled (404 subjects participated in both blood draws). Seropositivity was 50.19% at t0 and 99% at t1, with a significant difference in IgG titers. A higher proportion of residents were seropositive at t0 compared with HCWs, with significantly higher IgG titers among residents at both t0 and t1. Pre‐existing immunity also had a significant effect on postvaccination IgG titers. However, a significant difference in titers at t1 between HCWs and residents considering only participants seropositive at t0 was found, with higher median titers among previously seropositive residents. Conclusion Findings of this study provide scientific evidence endorsing the policy of universal vaccination in LTCFs.
ISSN:2398-8835
2398-8835
DOI:10.1002/hsr2.1087