Differential Microbial Signature Associated With Benign Prostatic Hyperplasia and Prostate Cancer

Apart from other risk factors, chronic inflammation is also associated with the onset of Prostate Cancer (PCa), wherein pathogen infection and tissue microbiome dysbiosis are known to play a major role in both inflammatory response and cancer development. However, except for a few studies, the link...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2022-07, Vol.12, p.894777-894777
Main Authors: Sarkar, Purandar, Malik, Samaresh, Banerjee, Anwesha, Datta, Chhanda, Pal, Dilip Kumar, Ghosh, Amlan, Saha, Abhik
Format: Article
Language:English
Subjects:
benign prostate hyperplasia
Cellular and Infection Microbiology
EBV
Epstein-Barr Virus Infections
Herpesvirus 4, Human - genetics
HPV
Humans
Male
microbiome
prostate cancer
Prostatic Hyperplasia - diagnosis
Prostatic Hyperplasia - genetics
Prostatic Neoplasms
RNA, Ribosomal, 16S - genetics
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Summary:Apart from other risk factors, chronic inflammation is also associated with the onset of Prostate Cancer (PCa), wherein pathogen infection and tissue microbiome dysbiosis are known to play a major role in both inflammatory response and cancer development. However, except for a few studies, the link between microbes and PCa remained poorly understood. To explore the potential microbiome signature associated with PCa in Indian patients, we investigated differential compositions of commensal bacteria among patients with benign prostatic hyperplasia (BPH) and PCa using 16S rRNA amplicon sequencing followed by qPCR analyses using two distinct primer sets. Using two independent cohorts, we show that , , and represent the three most abundant bacteria in diseased prostate lesions. LEfSe analyses identified that while are distinctly elevated in PCa samples, and are significantly enriched in BPH samples. Furthermore, we identify that a number of human tumor viruses, including Epstein-Barr virus (EBV) and hepatitis B virus (HBV), along with two high-risk human papillomaviruses - HPV-16 and HPV-18, are significantly associated with the PCa development and strongly correlated with PCa bacterial signature. The study may thus offer to develop a framework for exploiting this microbial signature for early diagnosis and prognosis of PCa development.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.894777