Involvement of Cellular Prion Protein in Invasion and Metastasis of Lung Cancer by Inducing Treg Cell Development

The cellular prion protein (PrP ) is a cell surface glycoprotein expressed in many cell types that plays an important role in normal cellular processes. However, an increase in PrP expression has been associated with a variety of human cancers, where it may be involved in resistance to the prolifera...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2021-02, Vol.11 (2), p.285
Main Authors: Cha, Seunghwa, Sin, Mi-Ji, Kim, Mo-Jong, Kim, Hee-Jun, Kim, Yong-Sun, Choi, Eun-Kyoung, Kim, Mi-Yeon
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Apoptosis
Breast cancer
CD25 antigen
Cell adhesion & migration
Cell proliferation
Cell surface
Cytotoxicity
Experiments
Foxp3 protein
Immunotherapy
Infections
Lung cancer
Lymphocytes T
ME7
Medical prognosis
Melanoma
Metastases
Metastasis
Microscopy
Natural killer cells
PD-L1 protein
prion
Prion protein
Prnp0/0
Proteins
Scrapie
Signal transduction
Software
Spleen
Tga20
Thymus gland
Transforming growth factor-b
Treg cells
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Summary:The cellular prion protein (PrP ) is a cell surface glycoprotein expressed in many cell types that plays an important role in normal cellular processes. However, an increase in PrP expression has been associated with a variety of human cancers, where it may be involved in resistance to the proliferation and metastasis of cancer cells. PrP-deficient ( ) and PrP-overexpressing (Tga20) mice were studied to evaluate the role of PrP in the invasion and metastasis of cancer. Tga20 mice, with increased PrP , died more quickly from lung cancer than did the mice, and this effect was associated with increased transforming growth factor-beta (TGF-β) and programmed death ligand-1 (PD-L1), which are important for the development and function of regulatory T (Treg) cells. The number of FoxP3 CD25 Treg cells was increased in Tga20 mice compared to mice, but there was no significant difference in either natural killer or cytotoxic T cell numbers. In addition, mice infected with the ME7 scrapie strain had decreased numbers of Treg cells and decreased expression of TGF-β and PD-L1. These results suggest that PrP plays an important role in invasion and metastasis of cancer cells by inducing Treg cells through upregulation of TGF-β and PD-L1 expression.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom11020285