Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions

• Published in: BMC infectious diseases 2017-08, Vol.17 (1), p.554-554, Article 554
• Main Authors: Hamed, Sonja, Behnes, Michael, Pauly, Dominic, Lepiorz, Dominic, Barre, Max, Becher, Tobias, Lang, Siegfried, Akin, Ibrahim, Borggrefe, Martin, Bertsch, Thomas, Hoffmann, Ursula
• Format: Article
• Language: English
• Subjects: Acute phase proteins; Adult; Aged; Aged, 80 and over; APACHE; Biomarkers; Biomarkers - blood; Blood; Body temperature; C-reactive protein; C-Reactive Protein - analysis; Calcitonin - blood; Care and treatment; Cytokines; Diagnosis; Diagnostic systems; Emergency medical care; Family medical history; Family physicians; Female; Heart rate; Hospitals; Humans; ICU; Infections; Infectious diseases; Inflammation; Intensive care; Intensive Care Units; Interleukin 6; Interleukin-6 - blood; Interleukins; Lactic acid; Male; Medicine; Middle Aged; Monocytes; Mortality; Patients; Pentraxin-3; Pentraxins; Plasma levels; Procalcitonin; Prognosis; Sepsis; Sepsis - blood; Sepsis - therapy; Sepsis-3; Septic shock; Serum Amyloid P-Component - analysis; Shock, Septic - blood; Shock, Septic - therapy; Studies; Toll-like receptors; Tumor necrosis factor; Tumor necrosis factor-TNF
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-017-2606-3

Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73-0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. NCT01535534 . Registered 14.02.2012.