Human supplementation with Pediococcus acidilactici GR-1 decreases heavy metals levels through modifying the gut microbiota and metabolome

Exposure to heavy metals (HMs) is a threat to human health. Although probiotics can detoxify HMs in animals, their effectiveness and mechanism of action in humans have not been studied well. Therefore, we conducted this randomized, double-blind, controlled trial on 152 occupational workers from the...

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Bibliographic Details
Published in:NPJ biofilms and microbiomes 2022-08, Vol.8 (1), p.63-63, Article 63
Main Authors: Feng, Pengya, Yang, Jinfeng, Zhao, Shuai, Ling, Zhenmin, Han, Rong, Wu, Ying, Salama, Ei-Sayed, Kakade, Apurva, Khan, Aman, Jin, Weilin, Zhang, Weibing, Jeon, Byong-Hun, Fan, Jingjing, Liu, Minrui, Mamtimin, Tursunay, Liu, Pu, Li, Xiangkai
Format: Article
Language:English
Subjects:
631/1647/514/2254
631/326/2522
Biomedical and Life Sciences
Copper
Digestive system
Gastrointestinal tract
Heavy metals
Intestinal microflora
Life Sciences
Medical Microbiology
Metabolomics
Metagenomics
Metal industry
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Microbiota
Nickel
Pediococcus acidilactici
Probiotics
Supplements
Yogurt
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Summary:Exposure to heavy metals (HMs) is a threat to human health. Although probiotics can detoxify HMs in animals, their effectiveness and mechanism of action in humans have not been studied well. Therefore, we conducted this randomized, double-blind, controlled trial on 152 occupational workers from the metal industry, an at-risk human population, to explore the effectiveness of probiotic yogurt in reducing HM levels. Participants were randomly assigned to two groups: one consumed probiotic yogurt containing the HM-resistant strain Pediococcus acidilactici GR-1 and the other consumed conventional yogurt for 12 weeks. Analysis of metal contents in the blood revealed that the consumption of probiotic yogurt resulted in a higher and faster decrease in copper (34.45%) and nickel (38.34%) levels in the blood than the consumption of conventional yogurt (16.41% and 27.57%, respectively). Metagenomic and metabolomic studies identified a close correlation between gut microbiota (GM) and host metabolism. Significantly enriched members of Blautia and Bifidobacterium correlated positively with the antioxidant capacities of GM and host. Further murine experiments confirmed the essential role of GM and protective effect of GR-1 on the antioxidative role of the intestine against copper. Thus, the use of probiotic yogurt may be an effective and affordable approach for combating toxic metal exposure through the protection of indigenous GM in humans. ClinicalTrials.gov identifier: ChiCTR2100053222
ISSN:2055-5008
2055-5008
DOI:10.1038/s41522-022-00326-8