Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications

Hypercholesterolemia is one of the most common chronic diseases in human. Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects. Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supp...

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Bibliographic Details
Published in:TheScientificWorld 2014-01, Vol.2014 (2014), p.1-12
Main Authors: Mehrbod, Parvaneh, Ariff, Arbakariya B., Rahman, Heshu Sulaiman, Khoramnia, Anahita, Abbasiliasi, Sahar, Bin Mokhtar, Mazlin, Bayat, Saadi, Khan Ayob, Mohd, Abd Ghani, Maaruf, Ajdari, Zahra, Ajdari, Daniel
Format: Article
Language:English
Subjects:
Animals
Anticholesteremic Agents - administration & dosage
Anticholesteremic Agents - isolation & purification
Cholesterol
Fermentation
Fermentation - physiology
Fermented foods
Food
Functional Food
Functional foods & nutraceuticals
Health aspects
Hypercholesterolemia - blood
Hypercholesterolemia - diet therapy
Hypocholesteremia
Lipids
Male
Metabolites
Monascus - isolation & purification
Rats
Rats, Sprague-Dawley
Risk factors
Rodents
Science
Studies
Treatment Outcome
Veterinary medicine
Yeast
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Summary:Hypercholesterolemia is one of the most common chronic diseases in human. Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects. Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supplement. In the present study, the hypocholesterolemic activity of Monascus purpureus FTC5391 fermented product ethanolic extract (MFPe) was investigated in hypercholesterolemic rats. Results showed that MFPe not only reduced the serum total cholesterol (TC), LDL-C, TG concentration, and TC/HDL-C ratio but also increased the HDL-C. Further, solid phase extraction (SPE) was carried out to obtain the hypocholesterolemic bioactive fraction. The high polar fraction of SPE increased the HDL-C (42%) and decreased the TC (53.3%), LDL-C (47%), and TG (50.7%) levels as well as TC/HDL-C ratio (69.1%) in serum. The GC-MS results of the active fraction revealed two main compounds, isosorbide and erythritol, which act as coronary vasodilator compounds.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2014/252647