Safety and outcomes of short-term use of peripheral vasoactive infusions in critically ill paediatric population in the emergency department

• Published in: Scientific reports 2022-09, Vol.12 (1), p.16340-7, Article 16340
• Main Authors: Yeong, Y. Q., Chan, J. M. F., Chan, J. K. Y., Huang, H. L., Ong, G. Y.
• Format: Article
• Language: English
• Subjects: 692/308/3187; 692/700; 692/700/1720; Child; Critical Illness - therapy; Dopamine; Emergency medical care; Emergency Service, Hospital; Humanities and Social Sciences; Humans; multidisciplinary; Oxygen; Pediatrics; Retrospective Studies; Science; Science (multidisciplinary); Septic shock; Vasoactive agents
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-20510-2

Early restoration of oxygen delivery to end organs in paediatric patients experiencing shock states is critical to optimizing outcomes. However, obtaining central access in paediatric patients may be challenging in non-intensive care settings. There is limited literature on the use of peripheral vasoactive infusions in the initial resuscitation of paediatric patients in the emergency department. The aims of this study were to report the associated complications of peripheral vasoactive infusions and describe our local experience on its use. This was a single-centre, retrospective study on all paediatric patients who received peripheral vasoactive infusions at our paediatric emergency department from 2009 to 2016. 65 patients were included in this study. No patients had any local or regional complications. The mean patient age was 8.29 years old (± 5.99). The most frequent diagnosis was septic shock (45, 69.2%). Dopamine was the most used peripheral vasoactive agent (71.2%). The median time to central agents was 2 h (IQR 1–4). 16(24.2%) received multiple peripheral infusions. We reported no complications of peripheral vasoactive infusions. Its use could serve as a bridge till central access is obtained. Considerations on the use of multiple peripheral vasoactive infusions in the emergency department setting needs further research.