Potential of trace elements as supplements for the metabolic control of Type 2 Diabetes Mellitus: A systematic review

[Display omitted] •Chromium and Selenium improve total antioxidant capacity and oxidative stress.•High doses of vanadium may result in adverse effects, leading to metabolic changes.•Selenium improves insulin sensitivity and inflammatory processes.•Zinc acts in phosphorylation of insulin receptors an...

Full description

Saved in:
Bibliographic Details
Published in:Journal of functional foods 2019-06, Vol.57, p.317-327
Main Authors: Moreira, Luiza de Paula Dias, Gomes, Jaqueline Vieira Piovezana, Mattar, Jéssica Bevenuto, Chaves, Larissa Oliveira, Martino, Hércia Stampini Duarte
Format: Article
Language:English
Subjects:
Glycemic profile
Inflammation
Lipid profile
Oligo-elements
Oxidative stress
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] •Chromium and Selenium improve total antioxidant capacity and oxidative stress.•High doses of vanadium may result in adverse effects, leading to metabolic changes.•Selenium improves insulin sensitivity and inflammatory processes.•Zinc acts in phosphorylation of insulin receptors and prevents high blood pressure. The objective of this review was to understand the role of trace elements in the form of supplements in metabolic control of Type 2 Diabetes Mellitus (T2DM). A systematic research was performed following PRISMA recommendations. Although 3236 studies were identified, only 18 studies composed of nine animal studies and nine clinical studies were included in this review. The included trace elements were Chromium (Cr), Selenium (Se), Zinc (Zn) and Vanadium (V). The time, dose and type of supplement varied among the studies. Se, Cr, Zn and V improved glycemic profile and antioxidant status while Se, Cr and Zn affected lipid profile. Se and Zn supplementation improved endothelial function. Also, Se modified inflammatory profile. In general, cautious supplementation of trace elements promotes the metabolic control of T2DM.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2019.04.015