Privacy-preserving harmonization via distributed ComBat

Challenges in clinical data sharing and the need to protect data privacy have led to the development and popularization of methods that do not require directly transferring patient data. In neuroimaging, integration of data across multiple institutions also introduces unwanted biases driven by scann...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2022-03, Vol.248, p.118822-118822, Article 118822
Main Authors: Chen, Andrew A., Luo, Chongliang, Chen, Yong, Shinohara, Russell T., Shou, Haochang
Format: Article
Language:English
Subjects:
Algorithms
Alzheimer's disease
ComBat
Datasets
Distributed analysis
Estimates
Harmonization
Humans
Information Dissemination
Magnetic fields
Medical imaging
Methods
Neurodegenerative diseases
Neuroimaging
Privacy
Privacy-preserving
Scanners
Site effect
Structure-function relationships
Systems Integration
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Summary:Challenges in clinical data sharing and the need to protect data privacy have led to the development and popularization of methods that do not require directly transferring patient data. In neuroimaging, integration of data across multiple institutions also introduces unwanted biases driven by scanner differences. These scanner effects have been shown by several research groups to severely affect downstream analyses. To facilitate the need of removing scanner effects in a distributed data setting, we introduce distributed ComBat, an adaptation of a popular harmonization method for multivariate data that borrows information across features. We present our fast and simple distributed algorithm and show that it yields equivalent results using data from the Alzheimer’s Disease Neuroimaging Initiative. Our method enables harmonization while ensuring maximal privacy protection, thus facilitating a broad range of downstream analyses in functional and structural imaging studies.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2021.118822