CDC light traps underestimate the protective efficacy of an indoor spatial repellent against bites from wild Anopheles arabiensis mosquitoes in Tanzania

Methods for evaluating efficacy of core malaria interventions in experimental and operational settings are well established but gaps exist for spatial repellents (SR). The objective of this study was to compare three different techniques: (1) collection of blood-fed mosquitoes (feeding), (2) human l...

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Bibliographic Details
Published in:Malaria journal 2023-04, Vol.22 (1), p.141-141, Article 141
Main Authors: Swai, Johnson Kyeba, Kibondo, Ummi Abdul, Ntabaliba, Watson Samuel, Ngoyani, Hassan Ahamad, Makungwa, Noely Otto, Mseka, Antony Pius, Chura, Madeleine Rose, Mascari, Thomas Michael, Moore, Sarah Jane
Format: Article
Language:English
Subjects:
Animals
Anopheles
Anopheles - physiology
Anopheles arabiensis
Aquatic insects
Blood
Centers for Disease Control and Prevention, U.S
Collections
Culicidae
Feeding
Human diseases
Humans
Indoor environments
Insect Repellents - pharmacology
Light traps
Malaria
Malaria - prevention & control
Medical laboratories
Mosquito Control - methods
Mosquito sampling
Mosquito Vectors
Mosquitoes
Pest control
Protective efficacy
Pyrethroids
Repellents
Spatial repellent
Tanzania
United States
Vector control
Vector-borne diseases
Volatile pyrethroid
Volunteers
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Summary:Methods for evaluating efficacy of core malaria interventions in experimental and operational settings are well established but gaps exist for spatial repellents (SR). The objective of this study was to compare three different techniques: (1) collection of blood-fed mosquitoes (feeding), (2) human landing catch (HLC), and (3) CDC light trap (CDC-LT) collections for measuring the indoor protective efficacy (PE) of the volatile pyrethroid SR product Mosquito Shield METHODS: The PE of Mosquito Shield against a wild population of pyrethroid-resistant Anopheles arabiensis mosquitoes was determined via feeding, HLC, or CDC-LT using four simultaneous 3 by 3 Latin squares (LS) run using 12 experimental huts in Tanzania. On any given night each technique was assigned to two huts with control and two huts with treatment. The LS were run twice over 18 nights to give a sample size of 72 replicates for each technique. Data were analysed by negative binomial regression. The PE of Mosquito Shield measured as feeding inhibition was 84% (95% confidence interval (CI) 58-94% [Incidence Rate Ratio (IRR) 0.16 (0.06-0.42), p 
ISSN:1475-2875
1475-2875
DOI:10.1186/s12936-023-04568-5