Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson’s disease

Objective: This study aimed to investigate the association of altered cortical thickness and FC with depression in PD. Methods: A total of 26 non-depressed PD patients (PD-ND), 30 PD patients with minor depression (PD-MnD), 32 PD patients with major depression (PD-MDD), and 30 healthy controls (HC)...

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Published in:Frontiers in aging neuroscience 2022-08, Vol.14, p.957997-957997
Main Authors: Yin, Weifang, Li, Anming, Yang, Baiyuan, Gao, Chao, Hu, Yanfei, Luo, Zhenglong, Li, Yuxia, Zhu, Yongyun, Zhou, Chuanbin, Ren, Hui, Li, Shimei, Yang, Xinglong
Format: Article
Language:English
Subjects:
Age
Atrophy
Biomarkers
Cerebellum
cortical atrophy
Data processing
Dementia
depression
Frontal gyrus
functional connectivity
Hospitals
Magnetic resonance imaging
Medical imaging
Mental depression
Mental disorders
Movement disorders
Neural networks
Neurodegenerative diseases
Neuroimaging
neuroimaging biomarkers
Neuropsychology
Neuroscience
Parkinson's disease
Pathophysiology
Patients
Quality of life
Statistical analysis
Superior temporal gyrus
Temporal gyrus
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Summary:Objective: This study aimed to investigate the association of altered cortical thickness and FC with depression in PD. Methods: A total of 26 non-depressed PD patients (PD-ND), 30 PD patients with minor depression (PD-MnD), 32 PD patients with major depression (PD-MDD), and 30 healthy controls (HC) were enrolled. Differences in cortical thickness among the four groups were assessed and the results were used to analyze FC differences in regions of cortical atrophy. Binary logistic regression and receiver operating characteristic (ROC) curve analyses were also performed to identify clinical features and neuroimaging biomarkers that might help predict PD-MDD. Results: Patients with PD-MDD showed decreased cortical thickness compared to patients with PD-ND in the left superior temporal and right rostral middle frontal gyri (RMFG), as well as weak FC between left superior temporal gyrus and right cerebellum posterior lobe and between right RMFG and right inferior frontal gyrus and insula. The combination of cortical thickness, FC and basic clinical features showed strong potential for predicting PD-MDD based on the area under the ROC curve (0.927, 95% CI 0.850-1.000, p < 0.001). Conclusions: Patients with PD-MDD show extensive cortical atrophy and FC alterations, suggesting that cortical thickness and FC may be neuroimaging-based diagnostic biomarkers for PD-MDD.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.957997