Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?

Non-unions are fractures that do not heal properly, resulting in a false joint formation at the fracture site. This condition leads to major health issues and imposes a burden on national healthcare systems. The etiology of non-unions is still not fully understood; therefore, we aimed to identify po...

Full description

Saved in:
Bibliographic Details
Published in:Bioengineering (Basel) 2024-11, Vol.11 (11), p.1135
Main Authors: Grgurević, Lovorka, Novak, Ruđer, Jambrošić, Lucija, Močibob, Marko, Jaganjac, Morana, Halasz, Mirna, Salai, Grgur, Hrkač, Stela, Milošević, Milan, Vlahović, Tomislav, Romić, Jeronim, Matičić, Dražen, Vidović, Dinko
Format: Article
Language:English
Subjects:
Alanine
Amyloid
Aspartate
B cells
Blood plasma
bone fracture
Bone healing
Cartilage
Chromatography
Cystatins
Data analysis
Down-regulation
FDA approval
Fractures
Glutamate
Glycoproteins
Health aspects
Lipid metabolism
Lipids
Low density lipoproteins
Mass spectrometry
Medical research
Medicine, Experimental
Metabolomics
non-union
Nonunion
Patients
Peptides
Plasma
Protein turnover
Proteins
Proteomics
Receptor density
Scientific imaging
Stem cells
Unions
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Non-unions are fractures that do not heal properly, resulting in a false joint formation at the fracture site. This condition leads to major health issues and imposes a burden on national healthcare systems. The etiology of non-unions is still not fully understood; therefore, we aimed to identify potential systemic factors that may contribute to their formation. We conducted a cross-sectional concomitant proteomic and metabolomic pilot study of blood plasma in patients with non-unions (N = 11) and compared them with patients with bone fracture in the normal active healing phase (N = 12). We found five significantly upregulated proteins in the non-union group: immunoglobulin heavy variable 3-74, immunoglobulin lambda variable 2-18, low-density lipoprotein receptor-related protein 4, zinc-alpha-2-glycoprotein, and serum amyloid A-1 protein; and we found one downregulated protein: cystatin-C. The metabolomic study found differences in alanine, aspartate and glutamate metabolism pathways between two groups. The combined results of proteomic and metabolomic analyses suggest that the dysregulation of lipid metabolism may contribute to non-union formation.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering11111135