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Enterocytozoon Bieneusi Infects Children With Inflammatory Bowel Disease Undergoing Immunosuppressive Treatment
Objectives: Patients with inflammatory bowel disease (IBD) are susceptible to intestinal opportunistic infections due to both defective mucosal immunity and altered immune response resulting from immunosuppressive treatment. Microsporidia infecting the gastrointestinal tract and causing diarrhoea ca...
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Published in: | Frontiers in medicine 2021-09, Vol.8, p.741751-741751 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Objectives:
Patients with inflammatory bowel disease (IBD) are susceptible to intestinal opportunistic infections due to both defective mucosal immunity and altered immune response resulting from immunosuppressive treatment. Microsporidia infecting the gastrointestinal tract and causing diarrhoea can potentially affect the course of IBD.
Methods:
Stool samples (90 IBD children and 121 healthy age-matched controls) were screened for
Encephalitozoon
spp. and
Enterocytozoon bieneusi
by microscopy and polymerase chain reaction followed by sequencing.
Results:
E. bieneusi
genotype D was found in seven out of 90 (7.8%) IBD children. No children from the control group were infected, making the pathogen prevalence in the IBD group significant (
P
= 0.002). Furthermore, infection was confirmed only in patients receiving immunosuppressive treatment (
P
= 0.013).
Conclusions:
Children with IBD are at risk of intestinal
E. bieneusi
infection, especially when receiving immunosuppressive treatment. Therefore, microsporidia should be considered as a significant infectious agent in this group of patients. |
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ISSN: | 2296-858X 2296-858X |
DOI: | 10.3389/fmed.2021.741751 |