Seroepidemiological study of human parvovirus B19 among human immunodeficiency virus-infected patients in a medium-sized city in Rio de Janeiro, Brazil

Parvovirus B19 (B-19) may cause chronic anaemia in immunosuppressed patients, including those infected with human immunodeficiency virus (HIV). We studied single serum samples from 261 consecutive HIV-infected patients using an enzyme immunoassay to detect IgG antibodies to B-19. The seroprevalence...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2009-09, Vol.104 (6), p.901-904
Main Authors: de Azevedo, Kátia Martins Lopes, Setúbal, Sérgio, Camacho, Luis Antônio Bastos, Velarde, Luis Guillermo Coca, de Oliveira, Solange Artimos
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - virology
anaemia
Antibodies, Viral - blood
Brazil - epidemiology
CD4-CD8 Ratio
DNA, Viral - analysis
Female
HIV infection
human parvovirus B19
human parvovirus B19 - seroprevalence - HIV infection - anaemia
Humans
Male
Middle Aged
PARASITOLOGY
Parvoviridae Infections - diagnosis
Parvoviridae Infections - epidemiology
Parvoviridae Infections - virology
Parvovirus B19, Human - genetics
Parvovirus B19, Human - immunology
Prevalence
Seroepidemiologic Studies
seroprevalence
TROPICAL MEDICINE
Young Adult
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Summary:Parvovirus B19 (B-19) may cause chronic anaemia in immunosuppressed patients, including those infected with human immunodeficiency virus (HIV). We studied single serum samples from 261 consecutive HIV-infected patients using an enzyme immunoassay to detect IgG antibodies to B-19. The seroprevalence of B-19-IgG was 62.8%. The differences in seroprevalence across gender, age, educational categories, year of collection of the serum samples, clinical and antiretroviral therapy characteristics, CD4+ count, CD4+ and CD8+ percentage and CD4+/CD8+ ratios were neither substantial nor statistically significant. There was a non-significant, inverse association between B-19 seropositivity and plasma HIV load and haemoglobin level. Our results indicated that 37.1% of patients might be susceptible to B-19 infection and remained at risk for being infected, mainly during epidemic periods. As B-19 infection can be treated with immune globulin preparations, it may be included in the diagnostic approach toward chronic anaemia in HIV-infected patients.
ISSN:1678-8060
0074-0276
1678-8060
0074-0276
DOI:10.1590/S0074-02762009000600014