Efficacy and safety of finerenone in individuals with type 2 diabetes mellitus complicated by diabetic kidney disease: A retrospective observational study

• Published in: Metabolism open 2024-12, Vol.24, p.100318, Article 100318
• Main Authors: Kawaguchi, Yuji, Hajika, Yuriko, Ashida, Narumi, Rinka, Maho, Hamai, Chie, Masumoto, Koji, Sawa, Jun, Hamazaki, Kenji, Kumeda, Yasuro
• Format: Article
• Language: English
• Subjects: Diabetic kidney disease; Estimated glomerular filtration rate; Finerenone; Original Research Paper; Type 2 diabetes mellitus; Urinary albumin-to-creatinine ratio
• ISSN: 2589-9368; 2589-9368
• DOI: 10.1016/j.metop.2024.100318

Early therapeutic interventions are necessary to reduce cardiovascular and renal composite endpoints in individuals with type 2 diabetes mellitus (T2DM) and diabetic kidney disease (DKD). Clinical trials have shown that finerenone suppresses cardiovascular and renal composite endpoints by reducing the urinary albumin-to-creatinine ratio (UACR) and suppressing the decline in the Estimated Glomerular Filtration Rate (eGFR). However, the efficacy and safety of finerenone in real-world clinical practice remain unclear. This study aimed to evaluate the reduction in the UACR as an efficacy endpoint as well as changes in eGFR and serum potassium levels as safety endpoints before and after finerenone administration. This retrospective observational study collected data from outpatients with T2DM and DKD upon initiation of finerenone treatment and 3 months after treatment. The primary efficacy endpoint was the change in the UACR from the start of finerenone treatment to after 3 months, while the primary safety endpoints were the changes in serum potassium levels and eGFR over the same period. The mean UACR significantly decreased from 668.6 mg/gCr at the start of finerenone treatment to 367.8 mg/gCr after 3 months (p  0.05). In individuals with T2DM and DKD, finerenone treatment significantly reduced the UACR, with no post-treatment changes in potassium levels or eGFRs. This trial was registered with the University Hospital Medical Information Network Clinical Trial Registry (UMIN000054821). •Finerenone administration significantly reduced the UACR in terms of efficacy.•Finerenone administration did not increase in potassium levels or eGFR.•Finerenone may reduce cardiovascular and renal composite endpoints.