Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens

Exploring the hypoxia adaptation mechanism of Tibetan chicken is of great significance for revealing the survival law of Tibetan chicken and plateau animal husbandry production. To investigate the hypoxia adaptation of Tibetan chickens (TBCs), an integrative metabolomic-transcriptomic analysis of th...

Full description

Saved in:
Bibliographic Details
Published in:BMC genomics 2024-02, Vol.25 (1), p.131-131, Article 131
Main Authors: Xue, Mingming, Yu, Runjie, Yang, Lixian, Xie, Fuyin, Fang, Meiying, Tang, Qiguo
Format: Article
Language:English
Subjects:
Adaptation
Adaptation (Physiology)
Altitude
Amino acids
Animal husbandry
Animal production
Biosynthesis
Chickens
Complications and side effects
Discriminant analysis
Embryogenesis
Embryonic development
Embryonic growth stage
Embryonic liver
Energy metabolism
Fatty acids
Gene expression
Genetic aspects
Health aspects
Hypoxia
Lipids
Liver
Mass spectrometry
Metabolic pathways
Metabolism
Metabolites
Metabolomics
Methods
Physiology
Poultry
RNA sequencing
Scientific imaging
Tibetan chickens
Transcriptomics
Tricarboxylic acid cycle
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c549t-dda8173b4361bb7b2b450fe0cf6e7690a152b1f6c1799b936467bf70b9f5528d3
container_end_page 131
container_issue 1
container_start_page 131
container_title BMC genomics
container_volume 25
creator Xue, Mingming
Yu, Runjie
Yang, Lixian
Xie, Fuyin
Fang, Meiying
Tang, Qiguo
description Exploring the hypoxia adaptation mechanism of Tibetan chicken is of great significance for revealing the survival law of Tibetan chicken and plateau animal husbandry production. To investigate the hypoxia adaptation of Tibetan chickens (TBCs), an integrative metabolomic-transcriptomic analysis of the liver on day 18 of embryonic development was performed. Dwarf laying chickens (DLCs), a lowland breed, were used as a control. A total of 1,908 metabolites were identified in both TBCs and DLCs. Energy metabolism and amino acid metabolism related differentially regulated metabolites (DRMs) were significantly enriched under hypoxia. Important metabolic pathways including the TCA cycle and arginine and proline metabolism were screened; PCK1, SUCLA2, and CPS1 were found to be altered under hypoxic conditions. In addition, integrated analysis suggested potential differences in mitochondrial function, which may play a crucial role in the study of chicken oxygen adaptation. These results suggest that hypoxia changed the gene expression and metabolic patterns of embryonic liver of TBCs compared to DLCs. Our study provides a basis for uncovering the molecular regulation mechanisms of hypoxia adaptation in TBCs with the potential application of hypoxia adaptation research for other animals living on the Qinghai-Tibet plateau, and may even contribute to the study of diseases caused by hypoxia.
doi_str_mv 10.1186/s12864-024-10030-w
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_df624b1f04f048259068e8c78dedcc1a</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A782198143</galeid><doaj_id>oai_doaj_org_article_df624b1f04f048259068e8c78dedcc1a</doaj_id><sourcerecordid>A782198143</sourcerecordid><originalsourceid>FETCH-LOGICAL-c549t-dda8173b4361bb7b2b450fe0cf6e7690a152b1f6c1799b936467bf70b9f5528d3</originalsourceid><addsrcrecordid>eNptkltvFCEYhidGYw_6B7wwk3ijF1M5DQNXpmk8bFJjovWaAAO7rDMwwsy2--_LdmrtGAMJ5OP5XsLLWxSvIDiDkNH3CSJGSQUQqSAAGFTXT4pjSBpYIUjJ00f7o-IkpS0AsGGofl4cYYYBYpwcF-qrGaUKXeidTqX0bTlG6ZOObhjnWrCl6VXcB-902bmdiamMZmdkV272Q7hxspStHEY5uuAP9JVTWdOXeuP0L-PTi-KZlV0yL-_X0-Lnp49XF1-qy2-fVxfnl5WuCR-rtpUMNlgRTKFSjUKK1MAaoC01DeVAwhopaKmGDeeKY0poo2wDFLd1jViLT4vVrNsGuRVDdL2MexGkE3eFENdCxtHpzojWUkSyGCB5Zks4oMww3bDWtFpDmbU-zFrDpPpcMz7b0i1ElyfebcQ67AQEDCPEWFZ4e68Qw-_JpFH0LmnTddKbMCWBOEKkxgDDjL75B92GKfrs1YGqa9Ywzv5Sa5lf4LwN-WJ9EBXn-VshZ5DgTJ39h8qjNfk3gzfW5fqi4d2iITOjuRnXckpJrH58X7JoZnUMKUVjHwyBQBwiKeZIihxJcRdJcZ2bXj-28qHlTwbxLUG829A</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2925587898</pqid></control><display><type>article</type><title>Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens</title><source>PubMed Central (Open Access)</source><source>Publicly Available Content Database</source><creator>Xue, Mingming ; Yu, Runjie ; Yang, Lixian ; Xie, Fuyin ; Fang, Meiying ; Tang, Qiguo</creator><creatorcontrib>Xue, Mingming ; Yu, Runjie ; Yang, Lixian ; Xie, Fuyin ; Fang, Meiying ; Tang, Qiguo</creatorcontrib><description>Exploring the hypoxia adaptation mechanism of Tibetan chicken is of great significance for revealing the survival law of Tibetan chicken and plateau animal husbandry production. To investigate the hypoxia adaptation of Tibetan chickens (TBCs), an integrative metabolomic-transcriptomic analysis of the liver on day 18 of embryonic development was performed. Dwarf laying chickens (DLCs), a lowland breed, were used as a control. A total of 1,908 metabolites were identified in both TBCs and DLCs. Energy metabolism and amino acid metabolism related differentially regulated metabolites (DRMs) were significantly enriched under hypoxia. Important metabolic pathways including the TCA cycle and arginine and proline metabolism were screened; PCK1, SUCLA2, and CPS1 were found to be altered under hypoxic conditions. In addition, integrated analysis suggested potential differences in mitochondrial function, which may play a crucial role in the study of chicken oxygen adaptation. These results suggest that hypoxia changed the gene expression and metabolic patterns of embryonic liver of TBCs compared to DLCs. Our study provides a basis for uncovering the molecular regulation mechanisms of hypoxia adaptation in TBCs with the potential application of hypoxia adaptation research for other animals living on the Qinghai-Tibet plateau, and may even contribute to the study of diseases caused by hypoxia.</description><identifier>ISSN: 1471-2164</identifier><identifier>EISSN: 1471-2164</identifier><identifier>DOI: 10.1186/s12864-024-10030-w</identifier><identifier>PMID: 38302894</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adaptation ; Adaptation (Physiology) ; Altitude ; Amino acids ; Animal husbandry ; Animal production ; Biosynthesis ; Chickens ; Complications and side effects ; Discriminant analysis ; Embryogenesis ; Embryonic development ; Embryonic growth stage ; Embryonic liver ; Energy metabolism ; Fatty acids ; Gene expression ; Genetic aspects ; Health aspects ; Hypoxia ; Lipids ; Liver ; Mass spectrometry ; Metabolic pathways ; Metabolism ; Metabolites ; Metabolomics ; Methods ; Physiology ; Poultry ; RNA sequencing ; Scientific imaging ; Tibetan chickens ; Transcriptomics ; Tricarboxylic acid cycle</subject><ispartof>BMC genomics, 2024-02, Vol.25 (1), p.131-131, Article 131</ispartof><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><rights>2024. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c549t-dda8173b4361bb7b2b450fe0cf6e7690a152b1f6c1799b936467bf70b9f5528d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10832288/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2925587898?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38302894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Mingming</creatorcontrib><creatorcontrib>Yu, Runjie</creatorcontrib><creatorcontrib>Yang, Lixian</creatorcontrib><creatorcontrib>Xie, Fuyin</creatorcontrib><creatorcontrib>Fang, Meiying</creatorcontrib><creatorcontrib>Tang, Qiguo</creatorcontrib><title>Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens</title><title>BMC genomics</title><addtitle>BMC Genomics</addtitle><description>Exploring the hypoxia adaptation mechanism of Tibetan chicken is of great significance for revealing the survival law of Tibetan chicken and plateau animal husbandry production. To investigate the hypoxia adaptation of Tibetan chickens (TBCs), an integrative metabolomic-transcriptomic analysis of the liver on day 18 of embryonic development was performed. Dwarf laying chickens (DLCs), a lowland breed, were used as a control. A total of 1,908 metabolites were identified in both TBCs and DLCs. Energy metabolism and amino acid metabolism related differentially regulated metabolites (DRMs) were significantly enriched under hypoxia. Important metabolic pathways including the TCA cycle and arginine and proline metabolism were screened; PCK1, SUCLA2, and CPS1 were found to be altered under hypoxic conditions. In addition, integrated analysis suggested potential differences in mitochondrial function, which may play a crucial role in the study of chicken oxygen adaptation. These results suggest that hypoxia changed the gene expression and metabolic patterns of embryonic liver of TBCs compared to DLCs. Our study provides a basis for uncovering the molecular regulation mechanisms of hypoxia adaptation in TBCs with the potential application of hypoxia adaptation research for other animals living on the Qinghai-Tibet plateau, and may even contribute to the study of diseases caused by hypoxia.</description><subject>Adaptation</subject><subject>Adaptation (Physiology)</subject><subject>Altitude</subject><subject>Amino acids</subject><subject>Animal husbandry</subject><subject>Animal production</subject><subject>Biosynthesis</subject><subject>Chickens</subject><subject>Complications and side effects</subject><subject>Discriminant analysis</subject><subject>Embryogenesis</subject><subject>Embryonic development</subject><subject>Embryonic growth stage</subject><subject>Embryonic liver</subject><subject>Energy metabolism</subject><subject>Fatty acids</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hypoxia</subject><subject>Lipids</subject><subject>Liver</subject><subject>Mass spectrometry</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Methods</subject><subject>Physiology</subject><subject>Poultry</subject><subject>RNA sequencing</subject><subject>Scientific imaging</subject><subject>Tibetan chickens</subject><subject>Transcriptomics</subject><subject>Tricarboxylic acid cycle</subject><issn>1471-2164</issn><issn>1471-2164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkltvFCEYhidGYw_6B7wwk3ijF1M5DQNXpmk8bFJjovWaAAO7rDMwwsy2--_LdmrtGAMJ5OP5XsLLWxSvIDiDkNH3CSJGSQUQqSAAGFTXT4pjSBpYIUjJ00f7o-IkpS0AsGGofl4cYYYBYpwcF-qrGaUKXeidTqX0bTlG6ZOObhjnWrCl6VXcB-902bmdiamMZmdkV272Q7hxspStHEY5uuAP9JVTWdOXeuP0L-PTi-KZlV0yL-_X0-Lnp49XF1-qy2-fVxfnl5WuCR-rtpUMNlgRTKFSjUKK1MAaoC01DeVAwhopaKmGDeeKY0poo2wDFLd1jViLT4vVrNsGuRVDdL2MexGkE3eFENdCxtHpzojWUkSyGCB5Zks4oMww3bDWtFpDmbU-zFrDpPpcMz7b0i1ElyfebcQ67AQEDCPEWFZ4e68Qw-_JpFH0LmnTddKbMCWBOEKkxgDDjL75B92GKfrs1YGqa9Ywzv5Sa5lf4LwN-WJ9EBXn-VshZ5DgTJ39h8qjNfk3gzfW5fqi4d2iITOjuRnXckpJrH58X7JoZnUMKUVjHwyBQBwiKeZIihxJcRdJcZ2bXj-28qHlTwbxLUG829A</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Xue, Mingming</creator><creator>Yu, Runjie</creator><creator>Yang, Lixian</creator><creator>Xie, Fuyin</creator><creator>Fang, Meiying</creator><creator>Tang, Qiguo</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240201</creationdate><title>Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens</title><author>Xue, Mingming ; Yu, Runjie ; Yang, Lixian ; Xie, Fuyin ; Fang, Meiying ; Tang, Qiguo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-dda8173b4361bb7b2b450fe0cf6e7690a152b1f6c1799b936467bf70b9f5528d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adaptation</topic><topic>Adaptation (Physiology)</topic><topic>Altitude</topic><topic>Amino acids</topic><topic>Animal husbandry</topic><topic>Animal production</topic><topic>Biosynthesis</topic><topic>Chickens</topic><topic>Complications and side effects</topic><topic>Discriminant analysis</topic><topic>Embryogenesis</topic><topic>Embryonic development</topic><topic>Embryonic growth stage</topic><topic>Embryonic liver</topic><topic>Energy metabolism</topic><topic>Fatty acids</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Hypoxia</topic><topic>Lipids</topic><topic>Liver</topic><topic>Mass spectrometry</topic><topic>Metabolic pathways</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Methods</topic><topic>Physiology</topic><topic>Poultry</topic><topic>RNA sequencing</topic><topic>Scientific imaging</topic><topic>Tibetan chickens</topic><topic>Transcriptomics</topic><topic>Tricarboxylic acid cycle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xue, Mingming</creatorcontrib><creatorcontrib>Yu, Runjie</creatorcontrib><creatorcontrib>Yang, Lixian</creatorcontrib><creatorcontrib>Xie, Fuyin</creatorcontrib><creatorcontrib>Fang, Meiying</creatorcontrib><creatorcontrib>Tang, Qiguo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xue, Mingming</au><au>Yu, Runjie</au><au>Yang, Lixian</au><au>Xie, Fuyin</au><au>Fang, Meiying</au><au>Tang, Qiguo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens</atitle><jtitle>BMC genomics</jtitle><addtitle>BMC Genomics</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>25</volume><issue>1</issue><spage>131</spage><epage>131</epage><pages>131-131</pages><artnum>131</artnum><issn>1471-2164</issn><eissn>1471-2164</eissn><abstract>Exploring the hypoxia adaptation mechanism of Tibetan chicken is of great significance for revealing the survival law of Tibetan chicken and plateau animal husbandry production. To investigate the hypoxia adaptation of Tibetan chickens (TBCs), an integrative metabolomic-transcriptomic analysis of the liver on day 18 of embryonic development was performed. Dwarf laying chickens (DLCs), a lowland breed, were used as a control. A total of 1,908 metabolites were identified in both TBCs and DLCs. Energy metabolism and amino acid metabolism related differentially regulated metabolites (DRMs) were significantly enriched under hypoxia. Important metabolic pathways including the TCA cycle and arginine and proline metabolism were screened; PCK1, SUCLA2, and CPS1 were found to be altered under hypoxic conditions. In addition, integrated analysis suggested potential differences in mitochondrial function, which may play a crucial role in the study of chicken oxygen adaptation. These results suggest that hypoxia changed the gene expression and metabolic patterns of embryonic liver of TBCs compared to DLCs. Our study provides a basis for uncovering the molecular regulation mechanisms of hypoxia adaptation in TBCs with the potential application of hypoxia adaptation research for other animals living on the Qinghai-Tibet plateau, and may even contribute to the study of diseases caused by hypoxia.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>38302894</pmid><doi>10.1186/s12864-024-10030-w</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1471-2164
ispartof BMC genomics, 2024-02, Vol.25 (1), p.131-131, Article 131
issn 1471-2164
1471-2164
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_df624b1f04f048259068e8c78dedcc1a
source PubMed Central (Open Access); Publicly Available Content Database
subjects Adaptation
Adaptation (Physiology)
Altitude
Amino acids
Animal husbandry
Animal production
Biosynthesis
Chickens
Complications and side effects
Discriminant analysis
Embryogenesis
Embryonic development
Embryonic growth stage
Embryonic liver
Energy metabolism
Fatty acids
Gene expression
Genetic aspects
Health aspects
Hypoxia
Lipids
Liver
Mass spectrometry
Metabolic pathways
Metabolism
Metabolites
Metabolomics
Methods
Physiology
Poultry
RNA sequencing
Scientific imaging
Tibetan chickens
Transcriptomics
Tricarboxylic acid cycle
title Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T05%3A27%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolomics%20and%20transcriptomics%20of%20embryonic%20livers%20reveal%20hypoxia%20adaptation%20of%20Tibetan%20chickens&rft.jtitle=BMC%20genomics&rft.au=Xue,%20Mingming&rft.date=2024-02-01&rft.volume=25&rft.issue=1&rft.spage=131&rft.epage=131&rft.pages=131-131&rft.artnum=131&rft.issn=1471-2164&rft.eissn=1471-2164&rft_id=info:doi/10.1186/s12864-024-10030-w&rft_dat=%3Cgale_doaj_%3EA782198143%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c549t-dda8173b4361bb7b2b450fe0cf6e7690a152b1f6c1799b936467bf70b9f5528d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2925587898&rft_id=info:pmid/38302894&rft_galeid=A782198143&rfr_iscdi=true