Mycoplasma pneumoniae Infection in Children Is a Risk Factor for Developing Allergic Diseases

Mycoplasma pneumoniae (MP) infection is the dominant cause of pneumonia in children. We sought to determine the relationship between MP infection and secondary allergic disease and to clarify the associated mechanisms of inflammatory response. A prospective study was performed among 1330 patients di...

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Bibliographic Details
Published in:TheScientificWorld 2014-01, Vol.2014 (2014), p.1-11
Main Authors: Chen, Xue-Jun, Pan, Yan-Xiang, Shao, Wen-Xia, Xu, Xiao-Jun, Ye, Qing
Format: Article
Language:English
Subjects:
Adolescent
Allergic reaction
Allergies
Allergy
Biomarkers - blood
Child
Child, Preschool
Children
Children & youth
China - epidemiology
Clinical Study
Comorbidity
Cytokines
Deoxyribonucleic acid
Development and progression
Disease
Diseases
DNA
Female
Hospitals
Humans
Hypersensitivity - blood
Hypersensitivity - diagnosis
Hypersensitivity - epidemiology
Immune status
Immunoglobulin E - blood
Infant
Infant, Newborn
Infections
Lymphocytes
Male
Mycoplasma infections
Mycoplasma pneumoniae
Patients
Pneumonia
Pneumonia, Mycoplasma - blood
Pneumonia, Mycoplasma - diagnosis
Pneumonia, Mycoplasma - epidemiology
Prevalence
Proteins
Risk Factors
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Summary:Mycoplasma pneumoniae (MP) infection is the dominant cause of pneumonia in children. We sought to determine the relationship between MP infection and secondary allergic disease and to clarify the associated mechanisms of inflammatory response. A prospective study was performed among 1330 patients diagnosed with pneumonia to investigate the patient immune status by determining the correlation between MP infection, immunoglobulin E (IgE) levels, and a spectrum of associated serum cytokines. Serum IgE, IL-4, IL-6, and IL-10 levels for MPP patients in the acute phase were obviously higher than those in the recovery phase ( P < 0.01 ). MPP patients with allergic conditions had increased serum IgE levels and increased IL-4/INF-γ ratio, and IgE and Eosinophil Cationic Protein were further elevated in patients who eventually developed secondary asthma changes. Patients with severe pneumonia and high clinical pulmonary infection scores presented higher levels of IL-4 and IL-5 in serum than those with low scores ( P < 0.01 ). The proportion of CD4+ and CD8+ T cells that secreted IL-4 was significantly increased in MPP patients with elevated IgE. Our data demonstrate a significant correlation between MP infection and IgE levels, which is associated with a Th1/Th2 cytokine imbalance.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2014/986527