Efficacy assessment of oral and sublingual sedation using alprazolam in implantology surgical procedures

• Published in: RGO - Revista Gaúcha de Odontologia 2019, Vol.67, p.e20190060
• Main Authors: ROSA, Antonio José Bittencourt da, SOTTO-MAIOR, Bruno Salles, FRANCISCHONE, Carlos Eduardo, RAMACCIATO, Juliana Cama, BRITO JÚNIOR, Rui Barbosa de, MOTTA, Rogério Heládio Lopes
• Format: Article
• Language: English
• Subjects: alprazolam; conscious sedation; dental implantation; DENTISTRY, ORAL SURGERY & MEDICINE
• ISSN: 0103-6971; 1981-8637; 1981-8637
• DOI: 10.1590/1981-86372019000603516

ABSTRACT Objective: The aim of this study was to evaluate the efficacy of two formulations of alprazolam (ALP) in patients undergoing oral implantology surgical procedures. Methods: A single-blinded randomized clinical study was performed with 52 volunteers (both genders) divided into 2 groups: G1 (n = 26) – oral administration of ALP (0.5 mg) 1h before surgical procedures; and G2 (n = 26) – sublingual administration of ALP (0.5mg) 30 minutes before surgery. Blood pressure (BP) and heart rate (HR) were evaluated. Corah dental anxiety scale (COR), visual analogic scale (VAS), Trieger test (TRI) and the perception questionnaire (PQ) were used to assess the level of anxiety and responses to formulations, respectively. All parameters were evaluated at three times (be-fore, during and postoperative). Results: For BP and HR no statistically significant differences were observed between periods for G1 and G2 (p> 0.05). For COR, most volunteers were classi-fied such as anxious or very anxious. For VAS, decreased anxiety was significant (p< 0.05) and no statistically significant differences between the two groups both in the period “pre” (p= 0.18) and “post” (p= 0.12) were observed. For TRI, there were no significant differences between the periods considering the number of points lost (p> 0.05). The anxiety reduction was significant (p< 0.05) for both formulations. As for PQ, both formulations showed good volunteers’ acceptance (p> 0.05), and they have not reported anterograde amnesia. Conclusion: It was concluded that both formulations were effective for sedation of the evaluated volunteers. RESUMO Objetivo: Avaliar a eficácia de duas formulações de alprazolam (ALP) na sedação de voluntários submetidos à procedimentos cirúrgicos de Implantodontia. Métodos: Foi realizado um estudo clinico, randomizado e cego, com 52 voluntários (ambos os gêneros) que foram divididos em 2 grupos: G1 (n=26) - administração de ALP (0,5mg) por via oral uma hora antes da sessão clínica; e G2 (n=26) - administração de ALP (0,5mg) por via sublingual 30 minutos antes da sessão clínica. Foram avaliadas a pressão arterial (PA) e frequência cardíaca (FC), e foram utilizadas a escala de ansiedade dental de Corah (COR) e escala analógica visual (EAV) para avaliação do nível de ansiedade. Adicionalmente, foram utilizados o teste de Trieger (TRI) e um questionário de percepção (QP) para avaliar as respostas aos tratamentos. Todos os parâmetros foram avaliados em 3 momentos (pré, trans e pós-oper