The upper respiratory tract microbiome of indigenous Orang Asli in north-eastern Peninsular Malaysia

Much microbiome research has focused on populations that are predominantly of European descent, and from narrow demographics that do not capture the socio-economic and lifestyle differences which impact human health. Here we examined the airway microbiomes of the Orang Asli, the indigenous peoples o...

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Published in:NPJ biofilms and microbiomes 2021-01, Vol.7 (1), p.1-1, Article 1
Main Authors: Cleary, David W., Morris, Denise E., Anderson, Rebecca A., Jones, Jessica, Alattraqchi, Ahmed Ghazi, A. Rahman, Nor Iza, Ismail, Salwani, Razali, Mohd Sayuti, Mohd Amin, Rahmah, Abd Aziz, Aniza, Esa, Nor Kamaruzaman, Amiruddin, Salman, Chew, Ching Hoong, Simin, Hafis, Abdullah, Ramle, Yeo, Chew Chieng, Clarke, Stuart C.
Format: Article
Language:English
Subjects:
631/326/1762
631/326/2565/2134
631/326/421
Biomedical and Life Sciences
Corynebacterium
Demography
Immunization
Indigenous peoples
Life Sciences
Medical Microbiology
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Microbiomes
Respiratory tract
rRNA 16S
Serotypes
Streptococcus infections
Vaccines
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Summary:Much microbiome research has focused on populations that are predominantly of European descent, and from narrow demographics that do not capture the socio-economic and lifestyle differences which impact human health. Here we examined the airway microbiomes of the Orang Asli, the indigenous peoples of Malaysia. A total of 130 participants were recruited from two sites in the north-eastern state of Terengganu in Peninsular Malaysia. Using 16S rRNA sequencing, the nasal microbiome was significantly more diverse in those aged 5–17 years compared to 50+ years ( p  = 0.023) and clustered by age (PERMANOVA analysis of the Bray–Curtis distance, p  = 0.001). Hierarchical clustering of Bray–Curtis dissimilarity scores revealed six microbiome clusters. The largest cluster ( n  = 28; 35.4%) had a marked abundance of Corynebacterium . In the oral microbiomes Streptococcus , Neisseria and Haemophilus were dominant. Using conventional microbiology, high levels of Staphylococcus aureus carriage were observed, particularly in the 18–65 age group ( n  = 17/36; 47.2% 95% CI: 30.9–63.5). The highest carriage of pneumococci was in the
ISSN:2055-5008
2055-5008
DOI:10.1038/s41522-020-00173-5