Gastro-protective effect of Biebersteinia multifida root hydro-methanolic extract in rats with ethanol-induced peptic ulcer

is one of the native plants of Iran and its root is used in folk medicine. This study aimed to evaluate the gastro-protective effect of the hydro-methanolic extract of this plant's roots against ethanol-induced gastric ulcer in rats. The following five groups of seven rats were included in this...

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Bibliographic Details
Published in:Avicenna journal of phytomedicine 2019-09, Vol.9 (5), p.410-418
Main Authors: Raeesi, Mahdi, Eskandari-Roozbahani, Narges, Shomali, Tahoora
Format: Article
Language:English
Subjects:
Anti-inflammatory
Antioxidant
Biebersteinia multifida
Peptic ulcer
Rat
Short Communication
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Summary:is one of the native plants of Iran and its root is used in folk medicine. This study aimed to evaluate the gastro-protective effect of the hydro-methanolic extract of this plant's roots against ethanol-induced gastric ulcer in rats. The following five groups of seven rats were included in this study: control (C), gastric ulcer (GU), control omeprazole (CO) and two treatment groups (the latter 3 groups were rats with gastric ulcer that orally received omeprazole, 20 mg/kg, or the root extract at 150 and 300 mg/kg (BM 150 and BM 300, respectively) 1 hour before ulcer induction). One hour after ulcer induction, blood sampling was performed and after sacrificing animals, the stomachs were immediately removed. Gastric mucosal injury was studied grossly to determine the number and area of gastric ulcers. The level of nitric oxide (NO) and total antioxidant capacity (TAC) in gastric mucosa as well as serum TNF-α were determined. In GU group, severe mucosal injuries were observed (p
ISSN:2228-7930
2228-7949
DOI:10.22038/ajp.2019.12902