Unveiling the Anti-Biofilm Property of Hydroxyapatite on Pseudomonas aeruginosa : Synthesis and Strategy

Biofilm-related nosocomial infections may cause a wide range of life-threatening infections. In this regard, biofilm is becoming a serious health burden due to its capability to develop resistance to natural and synthetic drugs. The utilization of nanoparticles that inhibit biofilm formation is one...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2023-01, Vol.15 (2), p.463
Main Authors: MubarakAli, Davoodbasha, Arunachalam, Kannappan, Lakshmanan, Murugan, Badar, Bazigha, Kim, Jung-Wan, Lee, Sang-Yul
Format: Article
Language:English
Subjects:
Acids
anti-biofilm
Bacterial infections
Biofilms
Communication
Composite materials
E coli
Hydroxyapatite
Microwaves
Nanocomposites
Nanoparticles
Nosocomial infections
Pathogens
Pseudomonas aeruginosa
Silver
Zinc oxides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biofilm-related nosocomial infections may cause a wide range of life-threatening infections. In this regard, biofilm is becoming a serious health burden due to its capability to develop resistance to natural and synthetic drugs. The utilization of nanoparticles that inhibit biofilm formation is one of the major strategies to control infections caused by biofilm-forming pathogens. Hydroxyapatite (HA) is a synthetic ceramic material having properties similar to natural bones. Herein, a co-precipitation method followed by microwave treatment was used to synthesize HA nanoparticles (HANPs). The resulting HANPs were characterized using X-ray diffraction and transmission electron microscopy. Then, their antibiofilm properties against ATCC 10145 were examined in vitro. The needle-shaped HANPs were 30 and 90 nm long in width and length, respectively. The synthesized HANPs inhibited the biofilm formation of ATCC 10145 in a concentration-dependent manner, which was validated by light and confocal laser scanning microscopy. Hence, this study demonstrated that HANPs could be used to control the biofilm-related infections of .
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15020463