Cross-Omics Analyses Reveal the Effects of Ambient PM2.5 Exposure on Hepatic Metabolism in Female Mice

Ambient particulate matter (PM2.5) is a potential risk factor for metabolic damage to the liver. Epidemiological studies suggest that elevated PM2.5 concentrations cause changes in hepatic metabolism, but there is a lack of laboratory evidence. Here, we aimed to evaluate the effects of PM2.5 exposur...

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Bibliographic Details
Published in:Toxics (Basel) 2024-08, Vol.12 (8), p.587
Main Authors: Yan, Ruifeng, Ji, Shaoyang, Ku, Tingting, Sang, Nan
Format: Article
Language:English
Subjects:
Abnormalities
Amino acids
bile acids
Biosynthesis
Chromatography
Damage accumulation
Data analysis
Epidemiology
Exposure
Fatty liver
Females
fine particulate matter
Genes
lipid
Lipid metabolism
Lipids
Liver
Liver diseases
Mass spectrometry
Metabolic disorders
Metabolic pathways
metabolic-associated fatty liver disease
Metabolites
Metabolomics
Organic acids
Particulate emissions
Particulate matter
Principal components analysis
Regulatory mechanisms (biology)
Risk factors
Scientific imaging
Software
Steroids
Toxicity
Transcriptomics
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Summary:Ambient particulate matter (PM2.5) is a potential risk factor for metabolic damage to the liver. Epidemiological studies suggest that elevated PM2.5 concentrations cause changes in hepatic metabolism, but there is a lack of laboratory evidence. Here, we aimed to evaluate the effects of PM2.5 exposure on liver metabolism in C57BL/6j female mice (10 months old) and to explore the mechanisms underlying metabolic alterations and differential gene expressions by combining metabolomics and transcriptomics analyses. The metabolomics results showed that PM2.5 exposure notably affected the metabolism of amino acids and organic acids and caused hepatic lipid and bile acid accumulation. The transcriptomic analyses revealed that PM2.5 exposure led to a series of metabolic pathway abnormalities, including steroid biosynthesis, steroid hormone biosynthesis, primary bile acid biosynthesis, etc. Among them, the changes in the bile acid pathway might be one of the causes of liver damage in mice. In conclusion, this study clarified the changes in liver metabolism in mice caused by PM2.5 exposure through combined transcriptomic and metabolomic analyses, revealed that abnormal bile acid metabolism is the key regulatory mechanism leading to metabolic-associated fatty liver disease (MAFLD) in mice, and provided laboratory evidence for further clarifying the effects of PM2.5 on body metabolism.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics12080587