The Role of Purinergic Receptors in Cancer-Induced Bone Pain

Cancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. The recent development of specific animal models has increased the understanding of the molecular and cellular mech...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Osteoporosis 2012-01, Vol.2012 (2012), p.195-206
Main Authors: Falk, Sarah, Uldall, Maria, Heegaard, Anne-Marie
Format: Article
Language:English
Subjects:
Bone cancer
Care and treatment
Cell receptors
Cellular signal transduction
Pain
Patient outcomes
Physiological aspects
Review
Risk factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. The recent development of specific animal models has increased the understanding of the molecular and cellular mechanisms underlying cancer-induced bone pain including the involvement of ATP and the purinergic receptors in the progression of the pain state. In nociception, ATP acts as an extracellular messenger to transmit sensory information both at the peripheral site of tissue damage and in the spinal cord. Several of the purinergic receptors have been shown to be important for the development and maintenance of neuropathic and inflammatory pain, and studies have demonstrated the importance of both peripheral and central mechanisms. We here provide an overview of the current literature on the role of purinergic receptors in cancer-induced bone pain with emphasis on some of the difficulties related to studying this complex pain state.
ISSN:2042-0064
2090-8059
2042-0064
DOI:10.1155/2012/758181