Nonmotor gastrointestinal disorders in older patients with Parkinson's disease: is there hope?

Despite the fact that nonmotor symptoms (NMS) like gastrointestinal (GI) complaints are frequently reported in Parkinson's disease (PD), no therapeutic guidelines are available. This study aimed to manage some lower GI-NMS in a group of patients with PD. A total of 40 patients (17 males, 23 fem...

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Bibliographic Details
Published in:Clinical interventions in aging 2016-01, Vol.11, p.1601-1608
Main Authors: Georgescu, Doina, Ancusa, Oana Elena, Georgescu, Liviu Andrei, Ionita, Ioana, Reisz, Daniela
Format: Article
Language:English
Subjects:
Abdomen
Age Factors
Aged
Antigens
Bifidobacterium
Care and treatment
Colonoscopy
Constipation
Diagnosis
Elderly patients
Female
Gastrointestinal Agents - therapeutic use
Gastrointestinal diseases
Gastrointestinal Diseases - diet therapy
Gastrointestinal Diseases - drug therapy
Gastrointestinal Diseases - etiology
Gastrointestinal Diseases - therapy
Health aspects
Humans
Lactobacillus acidophilus
Male
Microbiota
Older people
Original Research
Parkinson disease
Parkinson Disease - drug therapy
Parkinson Disease - physiopathology
Parkinson's disease
Pharmacy
Probiotics
Probiotics - therapeutic use
Quality of life
Software
Standard deviation
Thyroid gland
Trimebutine - therapeutic use
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Summary:Despite the fact that nonmotor symptoms (NMS) like gastrointestinal (GI) complaints are frequently reported in Parkinson's disease (PD), no therapeutic guidelines are available. This study aimed to manage some lower GI-NMS in a group of patients with PD. A total of 40 patients (17 males, 23 females; mean age 76.05±2.09 years) were randomly selected for this study. Patients were confirmed to have PD (modified Hoehn-Yars scale: 2.075±0.4) who had undergone levodopa or dopamine agonist treatment. In the non-motor symptoms questionnaire (NMS-Quest), regarding GI complaints, the following were recorded: abdominal pain, bloating, and constipation of mild-to-moderate severity. Laboratory studies, abdominal ultrasound, and upper and lower digestive endoscopies were performed to rule out organic issues. All patients increased their water intake to 2 L/d and alimentary fiber to 20-25 g/d. Twenty patients received trimebutine 200 mg three times daily half an hour before meals. The other 20 patients received probiotics (60 mg per-tablet of two lactic bacteria: and ), 2×/d, 1 hour after meals for 3 months along with the reassessment of GI complaints. Our results demonstrated that there were significant statistical differences in all assessed symptoms in the first group: 1.55±0.51 vs 0.6±0.5 (
ISSN:1178-1998
1176-9092
1178-1998
DOI:10.2147/CIA.S106284