G Protein-Coupled Receptors (GPCRs)-Mediated Calcium Signaling in Ovarian Cancer: Focus on GPCRs activated by Neurotransmitters and Inflammation-Associated Molecules

• Published in: International journal of molecular sciences 2019-11, Vol.20 (22), p.5568
• Main Authors: Predescu, Dragoș-Valentin, Crețoiu, Sanda Maria, Crețoiu, Dragoș, Pavelescu, Luciana Alexandra, Suciu, Nicolae, Radu, Beatrice Mihaela, Voinea, Silviu-Cristian
• Format: Article
• Language: English
• Subjects: Adenosine; Agonists; Androgens; Angiotensin; Angiotensin II; Animals; Antagonists; Atropine; Biomarkers, Tumor - metabolism; Bombesin; Bradykinin; Calcium; calcium mobilization; Calcium Signaling; Calcium signalling; Carbachol; Cell adhesion & migration; Cell growth; Cell proliferation; Cholecystokinin; Dopamine; Endothelin receptors; Endothelins; Estrogen receptors; Estrogens; Female; g-coupled protein receptors; gpcr cross-talk; Hormones; Humans; Inflammation; Inflammation - metabolism; Inflammation - pathology; Inflammation Mediators - metabolism; inflammation-associated molecules; Intestine; Kinases; Ligands; Metastasis; Neoplasm Proteins - metabolism; Nervous system; Neurotransmitter Agents - metabolism; Neurotransmitters; Ovarian cancer; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Ovaries; Pituitary (anterior); Prostaglandins; Proteins; Receptors, G-Protein-Coupled - metabolism; Review; Signal transduction; Tumor Microenvironment; Tumorigenesis; Tumors; Tyrosine; Vasoactive agents; Vasopressin
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20225568

G-coupled protein receptors (GCPR) involve several signaling pathways, some of them being coupled with intracellular calcium (Ca ) mobilization. GPCRs were involved in migration, invasion and metastasis of different types of cancers, including ovarian cancer. Many studies have discussed the essential contribution of GPCRs activated by steroid hormones in ovarian cancer. However, ovarian cancer is also associated with altered signals coming from the nervous system, the immune system or the inflammatory environment, in which GPCRs are 'sensing' these molecular signals. Many studies have been oriented so far on ovarian cell lines (most of them being of human cell lines), and only few studies based on animal models or clinical studies have been devoted to the expression changes or functional role of GPCRs in ovarian cancer. In this paper, we review the alterations of GPCRs activated by neurotransmitters (muscarinic receptors, serotonin receptors, dopamine receptors, adrenoceptors) or inflammation-associated molecules (bradykinin receptors, histamine receptors, chemokine receptors) in ovarian cancer and we discuss their potential as histological biomarkers.