Immunohistochemical over expression of p53 in head and neck Squamous cell carcinoma: clinical and prognostic significance

Immunohistochemical over expression of p53 is considered as a marker of poor prognosis in many cancers. Therefore, we aimed to evaluate immunohistochemical overexpression of p53 in 121 cases of head and neck Squamous cell carcinoma and its association with various clinicopathologic features and surv...

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Bibliographic Details
Published in:BMC research notes 2018-07, Vol.11 (1), p.433-433, Article 433
Main Authors: Hashmi, Atif Ali, Hussain, Zubaida Fida, Hashmi, Shumaila Kanwal, Irfan, Muhammad, Khan, Erum Yousuf, Faridi, Naveen, Khan, Amir, Edhi, Muhammad Muzzammil
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Adult
Age
Alcohol
Areca nut
Cancer therapies
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - metabolism
Chemotherapy
Development and progression
Female
Genetic aspects
Gutka
Head & neck cancer
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - metabolism
Head and Squamous cell carcinoma
Humans
Immunohistochemistry
Male
Medical prognosis
Middle Aged
Neck
Oropharyngeal Squamous cell carcinoma
p53
p53 Protein
Physiological aspects
Prognosis
Proteins
Research Note
Retrospective Studies
Squamous cell carcinoma
Survival analysis
Systematic review
Throat cancer
Tumor suppressor genes
Tumor Suppressor Protein p53 - metabolism
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Summary:Immunohistochemical over expression of p53 is considered as a marker of poor prognosis in many cancers. Therefore, we aimed to evaluate immunohistochemical overexpression of p53 in 121 cases of head and neck Squamous cell carcinoma and its association with various clinicopathologic features and survival. Total 66.1% (80 cases) expressed positive p53 expression, 34% (29 cases) revealed no p53 expression, while focal positive p53 expression was noted in 9.9% (12 Cases). Moreover, high p53 expression (> 70%) was noted in 26.4% (32 cases), while 19% (23 cases) showed 51-70% p53 expression. On the basis of intensity of p53 staining; strong p53 expression was noted in 39.7% (48 cases), while 24.8% (30 cases) and 10.7% (13 cases) revealed intermediate and weak p53 expression respectively. Significant association of p53 intensity of expression with extranodal extension and higher tumor grade (grades II and III) was noted. p53 is useful prognostic biomarker in head and neck Squamous cell carcinoma and therefore we suggest that more large scale studies are needed to evaluate its prognostic significance in our population.
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-018-3547-7