Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD

Most therapeutic candidates for treating attention-deficit hyperactivity disorder (ADHD) have focused on modulating the dopaminergic neurotransmission system with neurotrophic factors. Regulation of this system by transcranial direct current stimulation (tDCS) could contribute to the recovery of cog...

Full description

Saved in:
Bibliographic Details
Published in:eLife 2020-09, Vol.9
Main Authors: Jung, Da Hee, Ahn, Sung Min, Pak, Malk Eun, Lee, Hong Ju, Jung, Young Jin, Kim, Ki Bong, Shin, Yong-Il, Shin, Hwa Kyoung, Choi, Byung Tae
Format: Article
Language:English
Subjects:
Animals
anodal transcranial direct current stimulation
Attention Deficit Disorder with Hyperactivity - metabolism
Attention deficit hyperactivity disorder
brain-derived neurotrophic factor
Disease Models, Animal
dopaminergic neurotransmission factor
High definition television
Hypertension
Male
Nerve Growth Factors - metabolism
Neuroscience
Plasma Membrane Neurotransmitter Transport Proteins - metabolism
Prefrontal Cortex - chemistry
Prefrontal Cortex - metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Transcranial Direct Current Stimulation
Tyrosine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Most therapeutic candidates for treating attention-deficit hyperactivity disorder (ADHD) have focused on modulating the dopaminergic neurotransmission system with neurotrophic factors. Regulation of this system by transcranial direct current stimulation (tDCS) could contribute to the recovery of cognitive symptoms observed in patients with ADHD. Here, male spontaneously hypertensive rats (SHR) were subjected to consecutive high-definition tDCS (HD-tDCS) (20 min, 50 μA, current density 63.7 A/m , charge density 76.4 kC/m ) over the prefrontal cortex. This treatment alleviated cognitive deficits, with an increase in tyrosine hydroxylase and vesicular monoamine transporter two and significantly decreased plasma membrane reuptake transporter (DAT). HD-tDCS application increased the expression of several neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis. Our results suggest that anodal HD-tDCS over the prefrontal cortex may ameliorate cognitive dysfunction via regulation of DAT and BDNF in the mesocorticolimbic dopaminergic pathways, and therefore represents a potential adjuvant therapy for ADHD.
ISSN:2050-084X
2050-084X
DOI:10.7554/ELIFE.56359