Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation

Ultrasound-driven bioelectronics could offer a wireless scheme with sustainable power supply; however, current ultrasound implantable systems present critical challenges in biocompatibility and harvesting performance related to lead/lead-free piezoelectric materials and devices. Here, we report a le...

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Bibliographic Details
Published in:Nature communications 2024-05, Vol.15 (1), p.4017-4017, Article 4017
Main Authors: Wang, Qian, Zhang, Yusheng, Xue, Haoyue, Zeng, Yushun, Lu, Gengxi, Fan, Hongsong, Jiang, Laiming, Wu, Jiagang
Format: Article
Language:English
Subjects:
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Animals
Biocompatibility
Brain
Circuit boards
Deep brain stimulation
Deep Brain Stimulation - instrumentation
Deep Brain Stimulation - methods
Electrodes, Implanted
Epilepsy
Epilepsy - therapy
Equipment Design
Humanities and Social Sciences
Implants
Lead free
Male
multidisciplinary
Piezoelectricity
Prostheses and Implants
Rats
Rats, Sprague-Dawley
Science
Science (multidisciplinary)
Stimulation
Sustainable energy
Transducers
Transplants & implants
Ultrasonic imaging
Ultrasonic Waves
Ultrasound
Wireless Technology - instrumentation
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Summary:Ultrasound-driven bioelectronics could offer a wireless scheme with sustainable power supply; however, current ultrasound implantable systems present critical challenges in biocompatibility and harvesting performance related to lead/lead-free piezoelectric materials and devices. Here, we report a lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation, which integrates two developed lead-free sandwich porous 1-3-type piezoelectric composite elements with enhanced harvesting performance in a flexible printed circuit board. The implant is ultrasonically powered through a portable external dual-frequency transducer and generates programmable biphasic stimulus pulses in clinically relevant frequencies. Furthermore, we demonstrate ultrasound-driven implants for long-term biosafety therapy in deep brain stimulation through an epileptic rodent model. With biocompatibility and improved electrical performance, the lead-free materials and devices presented here could provide a promising platform for developing implantable ultrasonic electronics in the future. Ultrasound-driven bioelectronics offer a wireless scheme for implants. Here, the authors reported a lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-48250-z