Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain

Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disea...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-05, Vol.22 (9), p.4853
Main Authors: Joshi, Hari Prasad, Jo, Hyun-Jung, Kim, Yong-Ho, An, Seong-Bae, Park, Chul-Kyu, Han, Inbo
Format: Article
Language:English
Subjects:
Cell therapy
Chemokines
Chronic pain
Cytokines
Disease
Drugs
Immune system
Inflammation
Kinases
Literature reviews
Lymphocytes
mesenchymal stem cell
Morphine
Nervous system
neural stem cell
neuroinflammation
Neuromodulation
Neurons
neuropathic pain
Neuroprotection
Neutrophils
Pain
Pathogenesis
Pharmacology
Review
Signal transduction
Somatosensory system
Spinal cord
Stem cells
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Summary:Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disease mechanisms. Current pharmacological and nonpharmacological approaches can provide long-lasting pain relief to a limited percentage of patients and lack safe and effective treatment options. Therefore, scientists are focusing on the introduction of novel treatment approaches, such as stem cell therapy. A growing number of reports have highlighted the potential of stem cells for treating NP. In this review, we briefly introduce NP, current pharmacological and nonpharmacological treatments, and preclinical studies of stem cells to treat NP. In addition, we summarize stem cell mechanisms—including neuromodulation in treating NP. Literature searches were conducted using PubMed to provide an overview of the neuroprotective effects of stem cells with particular emphasis on recent translational research regarding stem cell-based treatment of NP, highlighting its potential as a novel therapeutic approach.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22094853