Loading…

A gelatin hydrogel nonwoven fabric improves outcomes of subcutaneous islet transplantation

Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously reported that a recombinant peptide (RCP) enhances subcutaneous islet engraftment. However, it is impractical for clinical use because RCP must be removed...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2023-07, Vol.13 (1), p.11968-12, Article 11968
Main Authors: Kanai, Norifumi, Inagaki, Akiko, Nakamura, Yasuhiro, Imura, Takehiro, Mitsugashira, Hiroaki, Saito, Ryusuke, Miyagi, Shigehito, Watanabe, Kimiko, Kamei, Takashi, Unno, Michiaki, Tabata, Yasuhiko, Goto, Masafumi
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously reported that a recombinant peptide (RCP) enhances subcutaneous islet engraftment. However, it is impractical for clinical use because RCP must be removed when transplanting islets. We herein investigated whether a novel bioabsorbable gelatin hydrogel nonwoven fabric (GHNF) could improve subcutaneous islet engraftment. A silicon spacer with or without GHNF was implanted into the subcutaneous space of diabetic mice. Syngeneic islets were transplanted into the pretreated space or intraportally (Ipo group). Blood glucose, intraperitoneal glucose tolerance, immunohistochemistry, CT angiography and gene expression were evaluated. The cure rate and glucose tolerance of the GHNF group were significantly better than in the control and Ipo groups ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-39212-4