Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis

Traumatic injury elicits a hyperinflammatory response and remodelling of the immune system leading to immuneparesis. This study aimed to evaluate whether traumatic injury results in a state of prematurely aged immune phenotype to relate this to clinical outcomes and a greater risk of developing addi...

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Bibliographic Details
Published in:Immunity & ageing 2022-12, Vol.19 (1), p.60-16, Article 60
Main Authors: Foster, Mark A, Bentley, Conor, Hazeldine, Jon, Acharjee, Animesh, Nahman, Ornit, Shen-Orr, Shai S, Lord, Janet M, Duggal, Niharika A
Format: Article
Language:English
Subjects:
Age
Aging
Biomarkers
CD8 antigen
Clinical outcomes
Cytokines
Disease susceptibility
Genetic aspects
Homeostasis
Immune response
Immune system
Immunesenescence
Immunological memory
Immunoregulation
Infections
Inflammation
Lymphocytes
Lymphocytes T
Lymphopenia
Memory cells
Mortality
Neutrophils
Patients
Phenotypes
Physiology
Risk factors
Sepsis
T cells
Trauma
Traumatic injury
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Summary:Traumatic injury elicits a hyperinflammatory response and remodelling of the immune system leading to immuneparesis. This study aimed to evaluate whether traumatic injury results in a state of prematurely aged immune phenotype to relate this to clinical outcomes and a greater risk of developing additional morbidities post-injury. Blood samples were collected from 57 critically injured patients with a mean Injury Severity Score (ISS) of 26 (range 15-75 years), mean age of 39.67 years (range 20-84 years), and 80.7% males, at days 3, 14, 28 and 60 post-hospital admission. 55 healthy controls (HC), mean age 40.57 years (range 20-85 years), 89.7% males were also recruited. The phenotype and frequency of adaptive immune cells were used to calculate the IMM-AGE score, an indicator of the degree of phenotypic ageing of the immune system. IMM-AGE was elevated in trauma patients at an early timepoint (day 3) in comparison with healthy controls (p 
ISSN:1742-4933
1742-4933
DOI:10.1186/s12979-022-00317-5