Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species

Antibiotic resistance is a global problem and bacterial biofilms contribute to its development. In this context, this study aimed to perform the synthesis and characterization of seven materials based on silica mesoporous nanoparticles functionalized with three types of fluoroquinolones, along with...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2023-07, Vol.16 (7), p.961
Main Authors: Ugalde-Arbizu, Maider, Aguilera-Correa, John Jairo, San Sebastian, Eider, Páez, Paulina L, Nogales, Estela, Esteban, Jaime, Gómez-Ruiz, Santiago
Format: Article
Language:English
Subjects:
Adsorption
Antibacterial agents
Antibiotics
Bacterial infections
biofilm
Biofilms
Chemical properties
copper
Copper compounds
Drug resistance
E coli
fluoroquinolone
Infections
Materials
Metals
Morphology
MSN
Nanoparticles
Particle size
Quinolone antibacterial agents
Quinolones
Silver
silver chloride
Silver compounds
Spectrum analysis
Testing
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Summary:Antibiotic resistance is a global problem and bacterial biofilms contribute to its development. In this context, this study aimed to perform the synthesis and characterization of seven materials based on silica mesoporous nanoparticles functionalized with three types of fluoroquinolones, along with Cu or Ag species to evaluate the antibacterial properties against , , , and , including clinical and multi-drug-resistant strains of and . In addition, in order to obtain an effective material to promote wound healing, a well-known proliferative agent, phenytoin sodium, was adsorbed onto one of the silver-functionalized materials. Furthermore, biofilm studies and the generation of reactive oxygen species (ROS) were also carried out to determine the antibacterial potential of the synthesized materials. In this sense, the Cu materials showed antibacterial activity against and , potentially due to increased ROS generation (up to 3 times), whereas the Ag materials exhibited a broader spectrum of activity, even inhibiting clinical strains of MRSA and In particular, the Ag material with phenytoin sodium showed the ability to reduce biofilm development by up to 55% and inhibit bacterial growth in a "wound-like medium" by up to 89.33%.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph16070961