Role of magnetic resonance spectroscopy in differential diagnosis of solitary pulmonary lesions

PURPOSE The aim of our study was to evaluate the availability of magnetic resonance spectroscopy (MRS) for the differentiation of benign or malignant pulmonary nodules and masses. METHODS A total of 59 patients (45 male, 14 female) with pulmonary nodules and masses were included in this prospective...

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Bibliographic Details
Published in:Diagnostic and interventional radiology (Ankara, Turkey) Turkey), 2021-11, Vol.27 (6), p.710-715
Main Authors: Hekimoglu, Azad, Ergun, Onur, Turan, Aynur, Turkmenoglu, Tugba Taskin, Hekimoglu, Baki
Format: Article
Language:English
Subjects:
Chest Imaging
Diagnosis
Diagnosis, Differential
Lung tumors
Methods
Nuclear magnetic resonance spectroscopy
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Summary:PURPOSE The aim of our study was to evaluate the availability of magnetic resonance spectroscopy (MRS) for the differentiation of benign or malignant pulmonary nodules and masses. METHODS A total of 59 patients (45 male, 14 female) with pulmonary nodules and masses were included in this prospective study. MRS was applied to the pulmonary lesions of the patients and choline levels were determined. Afterwards CT-guided percutaneous needle biopsy was performed. According to the biopsy results, pulmonary lesions were benign in 25 patients and malignant in 34 patients. RESULTS Choline levels were significantly higher in malignant lesions compared with benign lesions (p < 0.001). When the other conditions were kept constant, the probability of malignancy significantly increased by 17.38-fold (95% CI, 3.78-79.93) in those with choline levels >1.65 [micro]mol/g compared to those with choline levels [less than or equal to]1.65 [micro]mol/g (p < 0.001). CONCLUSION MRS is a noninvasive method that can be used in the differential diagnosis of pulmonary nodules and masses.
ISSN:1305-3825
1305-3612
DOI:10.5152/dir.2021.20419