Difficult-to-treat asthma patients from ethnic minority groups in central England are at an enhanced risk of house dust mite sensitisation

House dust mite (HDM) is the most common sensitising allergen in asthma. Ethnic minority groups (EMGs) in the UK are more likely to live in deprived conditionings with a greater exposure to HDM and other aero-allergens. To compare the ethnicity-based patterns of sensitisation to aero-allergens and t...

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Bibliographic Details
Published in:Clinical and translational allergy 2023-10, Vol.13 (10), p.e12303-n/a
Main Authors: Mansur, Adel H, Marsh, Julie, Bahron, Ali, Thomas, Maximillian, Walters, Gareth, Busby, John, Heaney, Liam G, Krishna, Mamidipudi Thirumala
Format: Article
Language:English
Subjects:
Allergens
Asthma
Biomarkers
Clinical outcomes
Demographics
disparities
Ethnicity
Food allergies
Hay fever
house dust mite
Immunotherapy
Minority & ethnic groups
Original
Physiology
Population
Questionnaires
Rhinitis
severe asthma
Software
Steroids
Variance analysis
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Summary:House dust mite (HDM) is the most common sensitising allergen in asthma. Ethnic minority groups (EMGs) in the UK are more likely to live in deprived conditionings with a greater exposure to HDM and other aero-allergens. To compare the ethnicity-based patterns of sensitisation to aero-allergens and the impact of ethnicity on clinical outcomes in patients with difficult-to-treat asthma (DTA). Data of patients with DTA were extracted from the registry of the Birmingham Regional Severe Asthma Service (BRSAS), which have a catchment population of 7.3million from Central England. Patients from White and EMG backgrounds were compared in terms of the prevalence of atopy, total serum immunoglobulin E (IgE), specific serum IgE (ssIgE) and asthma related clinical outcomes. Logistic regression analysis was conducted to explore ethnicity-based risk factors for HDM sensitisation. A total of 1272 patients [White 1016 (79.9%), EMG 256 (20.1%) EMG] with a median age of 51 years (range 16-97) were included in the analysis. Patients from EMG were more likely (64%) to reside in the worst scale of index of multiple deprivation (IMD) than the White patients (25.5%), p 
ISSN:2045-7022
2045-7022
DOI:10.1002/clt2.12303