The moderating effect of physical activity on the relationship between neutrophil count and depressive symptoms

Variations in immune cell counts can trigger depressive symptoms, while physical activity effectively reduces the risk and severity of depressive symptoms. This study, based on the NHANES database, analyzes the relationship between neutrophil count and depressive symptoms and explores the moderating...

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Bibliographic Details
Published in:Scientific reports 2024-06, Vol.14 (1), p.12647-12647
Main Authors: Guo, Zhaohui, Xie, Zhenwen, Wang, Peng, Li, Shufan, Xin, Xin, Wang, Xing
Format: Article
Language:English
Subjects:
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Adult
Aged
Cross-Sectional Studies
Depression - blood
Depression - immunology
Depressive Symptoms
Exercise
Female
Humanities and Social Sciences
Humans
Leukocyte Count
Leukocytes (neutrophilic)
Male
Mental depression
Middle Aged
Moderation model
multidisciplinary
Neutrophil
Neutrophils
Neutrophils - immunology
Physical activity
Risk reduction
Science
Science (multidisciplinary)
Self-assessment
Statistical analysis
Surveys and Questionnaires
Citations: Items that this one cites
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Summary:Variations in immune cell counts can trigger depressive symptoms, while physical activity effectively reduces the risk and severity of depressive symptoms. This study, based on the NHANES database, analyzes the relationship between neutrophil count and depressive symptoms and explores the moderating effect of physical activity on this relationship. Cross-sectional data from the NHANES database were extracted, including immune cell counts, PHQ-9 scores for self-assessment of depressive symptoms, and Global Physical Activity Questionnaire (GPAQ) scores (PA). The interrelations among physical activity, neutrophil count, and depressive symptoms were analyzed. After controlling for confounding factors, neutrophil count was found to have a significant role in identifying depressive symptoms with an odds ratio (OR) [95% Confidence Interval (CI)] = 1.13 [1.02, 1.251]; the moderating effect of physical activity on the impact of neutrophil count on depressive symptoms was statistically significant (coefficient = -0.0028, P  
ISSN:2045-2322
DOI:10.1038/s41598-024-63432-x