Hematopoietic stem cell heterogeneity and age-related platelet bias: implications for bone marrow transplantation and blood disorders

Hematopoietic stem cells (HSCs) are critical for maintaining lifelong blood production and immune function, especially in the context of bone marrow transplantation, where their ability to reconstruct multiple blood lineages is essential. However, recent studies have revealed that certain HSCs exhib...

Full description

Saved in:
Bibliographic Details
Published in:Stem cell research & therapy 2024-12, Vol.15 (1), p.459-4
Main Authors: Chen, Yalu, Shentu, Jianqiao, Lou, Hanqi, Xia, Yongming, Jiang, Yinyan, Duan, Shiwei
Format: Article
Language:English
Subjects:
Aging
Animals
Blood diseases
Blood disorders
Blood Platelets - metabolism
Bone marrow
Bone marrow transplantation
Bone Marrow Transplantation - methods
Health aspects
Hematologic Diseases - pathology
Hematologic Diseases - therapy
Hematopoietic Stem Cell Transplantation - methods
Hematopoietic stem cells
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - metabolism
Humans
Lineage bias
Medical research
Medicine, Experimental
Platelet-biased HSCs
RNA sequencing
Stem cells
Therapeutic strategies
Transplantation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hematopoietic stem cells (HSCs) are critical for maintaining lifelong blood production and immune function, especially in the context of bone marrow transplantation, where their ability to reconstruct multiple blood lineages is essential. However, recent studies have revealed that certain HSCs exhibit a bias toward platelet differentiation, termed platelet-biased HSCs (P-HSCs). This lineage bias, particularly pronounced with aging, can lead to imbalances in post-transplant blood recovery, negatively affecting patient outcomes. Research by Claus Nerlov's team has provided key insights into the heterogeneity of HSCs, focusing on the age-related expansion of P-HSCs. Using advanced techniques such as single-cell RNA sequencing and molecular barcoding, their work highlights the evolutionary conservation of platelet bias in HSCs across species. This work delves into these findings, discussing their clinical implications for bone marrow transplantation, aging-related blood disorders, and potential therapeutic strategies. Moreover, we address limitations in current methodologies and propose future directions for research to optimize HSC-based therapies and improve clinical outcomes in hematological diseases.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-024-04084-6