The role of gut microbiota in prostate inflammation and benign prostatic hyperplasia and its therapeutic implications

• Published in: Heliyon 2024-10, Vol.10 (19), p.e38302, Article e38302
• Main Authors: Chen, Jie, Chen, Bo, Lin, Bin, Huang, Yin, Li, Jinze, Li, Jin, Chen, Zeyu, Wang, Puze, Ran, Biao, Yang, Jiahao, Huang, Huijian, Liu, Liangren, Wei, Qiang, Ai, Jianzhong, Cao, Dehong
• Format: Article
• Language: English
• Subjects: Gut dysbiosis; Gut microbiota; Intestinal epithelial permeability; Lipopolysaccharide (LPS); Medicine; Prostate inflammation; Review; Short-chain fatty acids (SCFAs); Therapy
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2024.e38302

The gut microbiota thrives in a complex ecological environment and its dynamic balance is closely related to host health. Recent studies have shown that the occurrence of various diseases including prostate inflammation is related to the dysregulation of the gut microbiome. This review focus on the mechanisms by which the gut microbiota induces prostate inflammation and benign prostatic hyperplasia and its therapeutic implications. Publications related to gut microbiota, prostate inflammation, and benign prostatic hyperplasia (BPH) until April 2023 were systematically reviewed. The research questions were formulated using the Problem, Intervention, Comparison/Control, and Outcome (PICO) frameworks. Fifteen articles covering the relationship between the gut microbiota and prostate inflammation/BPH, the mechanisms by which the gut microbiota influences prostate inflammation and BPH, and potential therapeutic approaches targeting the gut microbiota for these conditions were included. Short-chain fatty acids (SCFAs), which are metabolites of the intestinal microbiota, protect the integrity of the intestinal barrier, regulate immunity, and inhibit inflammation. However, dysregulation of the gut microbiota significantly reduces the SCFA content in feces and impairs the integrity of the gut barrier, leading to the translocation of bacteria and bacterial components such as lipopolysaccharide, mediating the development of prostate inflammation through microbe-associated molecular patterns (MAMPs).