Burden of cerebral small vessel disease and changes of diastolic blood pressure affect clinical outcome after acute ischemic stroke

Elevated and low blood pressure (BP) may lead to poor functional outcome after ischemic stroke, which is conflicting. Hence, there must be another factor—such as cerebral small vessel disease (cSVD) -interacting with BP and thus, affecting outcome. Here, we investigate the relationship between BP an...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2023-12, Vol.13 (1), p.22070-22070, Article 22070
Main Authors: Gunkel, Sarah, Schötzau, Andreas, Fluri, Felix
Format: Article
Language:English
Subjects:
692/617/375
692/617/375/1370
692/617/375/534
692/617/375/599
Blood pressure
Humanities and Social Sciences
Ischemia
multidisciplinary
Science
Science (multidisciplinary)
Stroke
Vascular diseases
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Elevated and low blood pressure (BP) may lead to poor functional outcome after ischemic stroke, which is conflicting. Hence, there must be another factor—such as cerebral small vessel disease (cSVD) -interacting with BP and thus, affecting outcome. Here, we investigate the relationship between BP and cSVD regarding outcome after stroke. Data of 423/503 stroke patients were prospectively analyzed. Diastolic (DBP) and systolic BP (SBP) were collected on hospital admission (BP ad ) and over the first 72 h (BP 72h ). cSVD-burden was determined on MR-scans. Good functional outcome was defined as a modified Rankin Scale score ≤ 2 at hospital discharge and 12 months thereafter. cSVD was a predictor of poor outcome (OR 2.8; p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-49502-6