Transient thrombopenia after intravenous injection of certain fatty acids

Intravenous injections of various fatty acids in rabbits caused marked thrombopenia lasting 1–2 hr. The most active saturated fatty acids were myristic acid (14:0) and lauric acid (12:0). Activity decreased with increasing and decreasing chain length, but behenic acid (22:0) had, on a molar basis, a...

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Bibliographic Details
Published in:Journal of lipid research 1964-07, Vol.5 (3), p.378-384
Main Author: Zbinden, G
Format: Article
Language:English
Subjects:
Animals
Fatty Acids - pharmacology
Fatty Acids, Essential - pharmacology
Hydroxyindoleacetic Acid - urine
Linoleic Acids - pharmacology
Oleic Acids - pharmacology
Rabbits
Thrombocytopenia - chemically induced
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Summary:Intravenous injections of various fatty acids in rabbits caused marked thrombopenia lasting 1–2 hr. The most active saturated fatty acids were myristic acid (14:0) and lauric acid (12:0). Activity decreased with increasing and decreasing chain length, but behenic acid (22:0) had, on a molar basis, activity similar to that of lauric acid. Of the unsaturated fatty acids, oleic acid (18:1) was active only at high doses, whereas linoleic (18:2) and linolenic acid (18:3) had an effect comparable to palmitic acid (16:0). Intraperitoneal administration of the fatty acids caused no thrombopenia. The thrombo-penic effect of the fatty acids was greatly reduced if the solutions were mixed with serum before injection.
ISSN:0022-2275
DOI:10.1016/S0022-2275(20)40209-3