Relationship between Framingham Cardiovascular Risk Score and cognitive performance among ageing rural Indian participants: a cross-sectional analysis

ObjectiveThe burden of cardiovascular risk factors is increasing in India, which, in turn, can adversely impact cognition. Our objective was to examine the effect of cardiovascular risk factors measured by Framingham Risk Score (FRS) on cognitive performance among a cohort of healthy, ageing individ...

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Bibliographic Details
Published in:BMJ open 2023-11, Vol.13 (11), p.e074977-e074977
Main Authors: Mensegere, Abhishek Lingegowda, Sundarakumar, Jonas S, Diwakar, Latha, Issac, Thomas Gregor, Gangadhar, BN, Rao, Girish N, Rao, Naren P, Sivakumar, Palanimuthu T
Format: Article
Language:English
Subjects:
Aging
Blood pressure
cardiac epidemiology
Cholesterol
Cognitive ability
Cross-sectional studies
Dementia
Diabetes
Geriatric medicine
High density lipoprotein
Hypertension
Laboratories
Neuropsychology
Population
Risk factors
Rural areas
Women
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Summary:ObjectiveThe burden of cardiovascular risk factors is increasing in India, which, in turn, can adversely impact cognition. Our objective was to examine the effect of cardiovascular risk factors measured by Framingham Risk Score (FRS) on cognitive performance among a cohort of healthy, ageing individuals (n=3609) aged ≥45 years from rural India.DesignA cross-sectional analysis.SettingA rural community setting in southern India.ParticipantsHealthy, ageing, dementia-free participants, aged 45 years and above, belonging to the villages of Srinivaspura (a rural community located around 100 km from Bangalore, India), were recruited.Primary outcome measuresUsing a locally adapted, validated, computerised cognitive test battery, we assessed cognitive performance across multiple cognitive domains: attention, memory, language, executive functioning and visuospatial ability.ResultsThe median (IQR) age of the sample was 57 (50.65) and 50.5% were women. Multiple linear regression analysis showed that participants with higher FRS performed poorly in attention (visual attention (β=−0.018, p=0.041)), executive functioning (categorical fluency (β=−0.064, p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2023-074977