Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells

IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the prenatal thymus, and later persist as long-lived self-renewing cells in all kinds of tissues. However, their exchange between tissues and the mechanisms of their tissue-specific adaptation remain poorly understo...

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Bibliographic Details
Published in:	Cell reports (Cambridge) 2019-06, Vol.27 (12), p.3657-3671.e4
Main Authors:	Tan, Likai, Sandrock, Inga, Odak, Ivan, Aizenbud, Yuval, Wilharm, Anneke, Barros-Martins, Joana, Tabib, Yaara, Borchers, Alina, Amado, Tiago, Gangoda, Lahiru, Herold, Marco J., Schmidt-Supprian, Marc, Kisielow, Jan, Silva-Santos, Bruno, Koenecke, Christian, Hovav, Avi-Hai, Krebs, Christian, Prinz, Immo, Ravens, Sarina
Format:	Article
Language:	English
Subjects:	IL-17-producing γδ T cells Scart1 Scart2 single-cell transcriptomics tissue-resident γδ T cells Vγ6+ T cells
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