7 Prognostic factors for overall survival in patients with advanced melanoma treated with Anti-PD-1 therapy – the melimmune score

• Published in: Journal for immunotherapy of cancer 2020-11, Vol.8 (Suppl 3), p.A7-A7
• Main Authors: Lobo-Martins, Soraia, Martins-Branco, Diogo, Semedo, Patrícia Miguel, Alvim, Cecília Melo, Monteiro, Ana Maria, Vendrell, Inês, Gouveia, Emanuel, Passos, Maria José, Costa, Luís, Mansinho, André, Sousa, Rita Teixeira de
• Format: Article
• Language: English
• Subjects: Immunotherapy; Medical prognosis; Melanoma; Risk factors; Skin cancer
• ISSN: 2051-1426
• DOI: 10.1136/jitc-2020-SITC2020.0007

BackgroundImmune checkpoint inhibitors (ICI) have changed the paradigm of advanced malignant melanoma (MM). Several prognostic factors, mostly linked to inflammation, have been under scope to better select patients for such therapies. We aimed to build and apply a prognostic score in this setting.MethodsBaseline characteristics and outcomes on 147 patients with advanced MM treated with an anti-PD1 (nivolumab or pembrolizumab) in monotherapy, between Jan-2016 and Oct-2019, in the 1st, 2nd or 3rd line setting were collected from two centres in Portugal. Data cut-off for follow-up was May-2020. Cox proportional hazards regression was used to identify independent prognostic factors for OS.ResultsWith a median FU of 28.93 months (95% CI [22.52–33.54]), mOS for the whole cohort was 14.75 months (95% CI, [10.80–18.71]). Overall, 43 and 104 patients were treated with nivolumab and pembrolizumab, respectively. We identified four adverse prognostic factors that were independent predictors of bad prognosis: number of metastatic sites >2 (p