Dietary L-arabinose-induced gut dysbiosis exacerbates Salmonella infection outcome

The gut microbiota is essential for providing colonization resistance against pathogens. Dietary sugars markedly shift the composition of the intestinal microbiota and alter host susceptibility to enteric infections. Here, we demonstrate the effect of L-arabinose on bacterial infection by using a mo...

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Bibliographic Details
Published in:mSystems 2024-08, Vol.9 (8), p.e0052224
Main Authors: Yu, Jingchen, Tang, Huang, Zhou, Ning, Wang, Zuoqiang, Huang, Wanqiu, Chen, Yana, Wang, Danni, Ni, Jinjing, Lu, Jie, Yao, Yu-Feng
Format: Article
Language:English
Subjects:
Animals
Arabinose - pharmacology
Dysbiosis - microbiology
Enterobacteriaceae - drug effects
Gastrointestinal Microbiome - drug effects
L-arabinose
Male
metabolism
Mice
Mice, Inbred C57BL
microbiota
Pathogenesis and Host Response
Research Article
Salmonella
Salmonella Infections - microbiology
Salmonella typhimurium - drug effects
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Summary:The gut microbiota is essential for providing colonization resistance against pathogens. Dietary sugars markedly shift the composition of the intestinal microbiota and alter host susceptibility to enteric infections. Here, we demonstrate the effect of L-arabinose on bacterial infection by using a mouse infection model with serovar Typhimurium ( . Tm). In the presence of microbiota, L-arabinose induces a dramatic expansion of , thereby decreasing the microbiota diversity and causing more severe systemic infection. However, L-arabinose supplementation does not alter the disease progression of infection in a microbiota-depleted mouse model. More importantly, short-term supplementation of L-arabinose fails to exert anti-diabetic effects in -infected hyperglycemia mice and still promotes infection. Overall, our work reveals that a high intake of dietary L-arabinose supports a bloom of in -infected gut, further accelerating the process of systemic infection.IMPORTANCEL-arabinose is a promising natural sweetener and food additive for the regulation of hyperglycemia. Since diabetic subjects are more susceptible to infections, the safety of dietary L-arabinose in diabetic patients experiencing infection remains a concern. Our findings reveal that L-arabinose exacerbates infection outcome by inducing gut microbiota dysbiosis in mice. High dietary intake of L-arabinose may be deleterious for diabetic individuals undergoing infection.
ISSN:2379-5077
2379-5077
DOI:10.1128/msystems.00522-24